Abdulrazzaq, Inas F, Kareem Jabbar, Mohammed, Hasan Najm, Asawer, Sabeeh Alkhazali, Alaa, Sabah Bustani, Ghadeer (2026). Assessment of Cyclophosphamide-Induced Nephrotoxicity in a Preclinical Model and Evaluation of the Protective Efficacy of Sylvestroside I via Modulation of Pro-Inflammatory Cytokine Pathways. , 23(171-ویژه نامه), 248-261. doi: 10.48311/fsct.2026.119070.83044
Inas F Abdulrazzaq; Mohammed Kareem Jabbar; Asawer Hasan Najm; Alaa Sabeeh Alkhazali; Ghadeer Sabah Bustani. "Assessment of Cyclophosphamide-Induced Nephrotoxicity in a Preclinical Model and Evaluation of the Protective Efficacy of Sylvestroside I via Modulation of Pro-Inflammatory Cytokine Pathways". , 23, 171-ویژه نامه, 2026, 248-261. doi: 10.48311/fsct.2026.119070.83044
Abdulrazzaq, Inas F, Kareem Jabbar, Mohammed, Hasan Najm, Asawer, Sabeeh Alkhazali, Alaa, Sabah Bustani, Ghadeer (2026). 'Assessment of Cyclophosphamide-Induced Nephrotoxicity in a Preclinical Model and Evaluation of the Protective Efficacy of Sylvestroside I via Modulation of Pro-Inflammatory Cytokine Pathways', , 23(171-ویژه نامه), pp. 248-261. doi: 10.48311/fsct.2026.119070.83044
Abdulrazzaq, Inas F, Kareem Jabbar, Mohammed, Hasan Najm, Asawer, Sabeeh Alkhazali, Alaa, Sabah Bustani, Ghadeer Assessment of Cyclophosphamide-Induced Nephrotoxicity in a Preclinical Model and Evaluation of the Protective Efficacy of Sylvestroside I via Modulation of Pro-Inflammatory Cytokine Pathways. , 2026; 23(171-ویژه نامه): 248-261. doi: 10.48311/fsct.2026.119070.83044

Assessment of Cyclophosphamide-Induced Nephrotoxicity in a Preclinical Model and Evaluation of the Protective Efficacy of Sylvestroside I via Modulation of Pro-Inflammatory Cytokine Pathways

مجله علوم و صنایع غذایی ایران
Volume 23, 171-ویژه نامه, February 1405, Pages 248-261    PDF (408.77 K)
Document Type: مقاله پژوهشی
DOI: 10.48311/fsct.2026.119070.83044
Authors
Inas F Abdulrazzaq1; Mohammed Kareem Jabbar2; Asawer Hasan Najm3; Alaa Sabeeh Alkhazali4; Ghadeer Sabah Bustani* 5
1Department of Pharmaceutics, Faculty of Pharmacy, Kufa University, Al-Najaf, Iraq
2Alkafeel university
3Al-Bayan University, Baghdad, Iraq
4Al-Zahrawi University college
5The Islamic University, Najaf, Iraq.
Abstract
This study investigated the protective efficacy of Sylvestroside I (SYL), a secoiridoid glycoside of potential botanical origin, against CYP-induced renal injury in a preclinical model. Forty male Wistar rats were allocated into four groups: Control, CYP-only (200 mg/kg, i.p.), SYL-only (50 mg/kg/day, oral), and CYP+SYL. After a 30-day experimental period, renal function was assessed via serum creatinine and blood urea nitrogen (BUN). Oxidative stress was evaluated by measuring malondialdehyde (MDA) and total antioxidant capacity (TAC). Pro-inflammatory (TNF-α, IL-6) and protective (IL-22) cytokines were quantified, and renal histopathology was examined. CYP administration significantly impaired renal function, elevated oxidative stress (increased MDA, decreased TAC), disrupted cytokine balance (elevated TNF-α and IL-6, reduced IL-22), and caused severe histopathological damage. Sylvestroside I co-treatment markedly attenuated these effects, normalizing renal biomarkers, enhancing antioxidant status, restoring cytokine levels, and preserving renal tissue architecture. The results demonstrate that Sylvestroside I exerts potent renoprotective effects against CYP-induced toxicity, primarily through antioxidant and anti-inflammatory mechanisms. These findings position Sylvestroside I as a promising candidate for further development within the context of functional ingredients or nutraceutical strategies aimed at supporting renal health and reducing chemical-induced tissue injury.
Keywords
Cyclophosphamide; Sylvestroside I; Nephrotoxicity; Oxidative stress; Cytokines
References
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