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Showing 3 results for shirani bidabadi
Volume 18, Issue 112 (May 2021)
Abstract
Malva sylvestris belongs to Malvaceae familyThe biological active compounds of Malva sylvestris describe probably it’s biological activities and therapeutic activity. The purpose of this study was to investigate the antibacterial effect of Malva sylvestris on some pathogenic bacteria “in vitro”.In this study, the extraction was carried out by the maceration method. The pour plate method and disk diffusion method were adopted to determine the susceptibility of the pathogenic strains against Malva sylvestris extracts. The broth microdilution and fractional inhibitory concentration index (FICI) were employed to determine antimicrobial effect. The minimum bactericidal concentration was measured by pour plate method. The concentration 100 mg/ml of the ethanolic extract showed the best result on Streptococcus pyogenes and Staphylococcus aureus (p<0.05). Enterobacter aeruginosa was resistant to most of the aqueous and ethanolic Malva sylvestris extracts. Minimum inhibitory concentration of the ethanolic extract of Malva sylvestris for Streptococcus pyogenes, Staphylococcus aureus, Escherichia coli and Enterobacter aeruginosa were 8, 8, 64 and 64 mg/ml, respectively and the aqueous extract were 16, 32, 128, and 128 mg/ml, respectively.The ethanolic extract of Malva sylvestris had more inhibitory effect than the aqueous extracts on pathogenic strains. Furthermore, aqueous and ethanolic Malva sylvestris extracts showed greater inhibitory effect on gram-positive bacteria in comparison with gram-negative bacteria.
Volume 19, Issue 122 (April 2022)
Abstract
Promising secondary metabolites of brown algae have been given particular importance, due to their various biological activities. In the present study, two extraction methods including maceration and ultrasound were performed to prepare extracts from brown algae including Padina distromatic, then, aimed to evaluate antioxidant, antimicrobial, and anti-Alzheimer’s activities of extracts. Padina algae extract prepared by ultrasound method had higher total phenol (43.25 mg GAE/g) and flavonoid content (24.59 mg QE/gDA). However, the maximum antioxidant activity was observed in algae extract prepared by maceration method. Padina algae extract prepared by ultrasound method had the highest inhibitory activity of acetylcholinesterase and the strongest inhibition of nitric oxide production was observed in this extract. Escherichia coli and Listeria innocua bacteria were more resistant to Padina algae extract than other microorganisms and the results of microbial test showed that Padina algae extract prepared by ultrasound method was more antimicrobial than maceration method. Collectively, the obtained results provide valuable evidence for antioxidant, anti-Alzheimer, and antimicrobial activity driven by Padina distromatic extracts which can highlight their possible approach in the therapeutic utilization.
Volume 20, Issue 138 (August 2023)
Abstract
Microencapsulation of bioactive compounds in lipid carriers, such as liposomes, in addition to improving stability during storage by increasing bioavailability and controlled release, increases the efficiency of these compounds in vivo. The studies conducted on Padina algae show the existence of a high level of phenolic and antimicrobial compounds. Also, this alga has a significant amount of polyphenols with antioxidant and anti-AChE (acetylcholinesterase) properties, which can be used as a supplement to improve neurological disorders. Therefore, the purpose of this research was to produce and investigate the structural properties of nanoliposomes containing Padina algae extract using the heating method. The particle size of nanoliposomes produced at varying levels of lecithin and loaded extract was obtained in the range between 318 and 60 nm. The resulting values for the polydispersity index and zeta potential indicate the uniformity of the produced particles along with the high electrostatic repulsion between the particles. The ability to load liposome particles at the lowest level of wall substance and the highest concentration level of the extract reached 52.8±0.3% in this research. Evaluation of the morphological characteristics of the structure using a transmission electron microscope shows the formation of uniform particles with a spherical geometry. The results of this research show the ability to produce a liposome structure containing Padina algae extract with suitable structural properties. These results can improve the prospect of possible use of this extract with a therapeutic approach.