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The first performance of the home is to create shelter, a haven which provides peace for inhabitants. Village House is a safe and reliable "inner place" against "external environment" with the extent of the wild nature. Therefore, the first performance of the home is primary need of rural people. The formation of the house is affected by a variety of environmental factors of three surrounding environments which in different species are formed based on special regional and local materials of the area by natives of the area.
In fact, the most important characteristic of rural homes, especially (Gilan) is simplicity and harmony with the natural environment surrounding them, in such a way that, a building not only is not a waste element that is added to the environment, but is risen from its surroundings, and the stability is reached due to its exposure.
conditions, not only has led to a different appearance of the buildings in the area, but due to the abundant use of wood and plant fibers in the building, and special properties of these materials, methods of construction in Gilan is distinct from other parts of Iran. Studying traditional methods of construction in Gilan to identify a species of "architecture in harmony with nature", Leads us to full interaction of man and the surrounding environment, that all of them indicate Intelligent human knowledge in time with the technical limitations of construction, and the sense of respect for nature.
As architectural elements and building components, all in order to build a dynamic architecture in this particular area of the building not only by benefiting from natural curran in the summer leads to climate comfort in the spring and summer, but in winter with a layer of semi-enclosed elements, such as Faken, reduces the amount of heat exchange between indoor and the surrounding environment.
Accordingly, the logic of construction and materials are selected based on potential and natural resources in the region and leads to use the local materials, combining fences, columns, headers and wooden beams and flowers used in walls, decoration by flowers and roof with four slopes are considered as individual components of a vernacular architecture, that in the passage of time has damaged stability of the building like natural disasters such as floods and earthquakes, which is considered as an effective factor among the indicator species in each region.
In Gilan geographic reach, which air humidity and rainfall is very high, rural housing should not only meet human needs related to shelter, but must include climatic comfort relatively. As such, residential building must be constructed in such a way that reduxes moisture in the environment over human tolerance to have proper temperature and humidity conditions. In this area, because of moderate temperatures in many times of the year, reduced air humidity provides comfort because discomfort in summer is felt due to high relative humidity of the air at all times a day. So, wind can move easily in order to repel moisture around the body and the human environment.
The relationship between the building and the environment is considered as the most obvious aesthetic features of Gilan rural buildings, which is rooted in geography, cultural issues and style life in Gilan. The lack of tangible boundary between inside and outside has given to it different effects compared with the central regions of Iran.
The houses of the area are generally built either in the direction of East or with a little rotation from East to South and this is due to the use of maximum sunlight and air flow. The used materials are indigenous as other rural areas of Gilan and available materials are used. The walls in this region are mainly the combination between the "Chineei" 1 "Zegali" 2 and completely Zegali. Because of the abundance of straw in the area,”Kolosh”3 is used as Zegal in the walls. In fact, all the art of living in the Gilan plain can be summarized in coping with difficult climatic conditions such as annual rainfall by almost 1280 mm, the humidity between 70 to 90 percent and temperature fluctuation between * 20 and * 37 .
In different parts of the plains of Gilan where the climatic characteristics cause a particular kind of architecture, outward-oriented architecture, regardless of the contradictions and complexities of construction technique, and variations in the utilization of local and available materials, we're seeing similarities in the scheme of this type of architecture, the majority of similarities in these buildings include:
The existence of the porch and hallway in a four-walled building that most biological environments.
Get the limited space and enclosed in the heart of the monument and surrounded by a hallway and porch for winter time.
Multi-layer being the main views and spaces with a maximum porosity in the outermost level.
The height of the residential parts of the getting off the ground.
Placement comfy wooden stairs without an intermediary style that the relationship between the grounds and the supply of housing.
The mass use of plant and wood materials and uncoated amood.
The four characteristics of the dwellings of the plain Gila can be distinguished from includes the following items:
I. The height of the Earth's surface to protect it against moisture in the ground.
II. Fans with steep slope.
III. The existence of one or more of the aisle and the porch in views.
IV. Construction of houses based on vertical plan common build dwellings that central in Iran (Making room on the horizontal inner courtyard) is different
This research seeks to analyze the body of one of the native habitat of the index and the geographical boundaries of Gilan plain areas exclusively to the analysis method - described by Sachs and method of analysis techniques - modeling Builder designed with energy simulation software to evaluate a sample of their unit. Accordingly, the use of library studies on the described manner, the morphology of Gilan and provide basic concepts on completion of organ literature as early as the theoretical basis. The use of macro and micro-scale field studies of settlements to analyze the climate and the physical samples for example in the form of software modeling background design study builder and table Sachs contributed.
At the end of these studies show, as well as comfort in Gilan native settlements for rural residents and require the passage of time has been granted, Today, the role of climate change in temperate climate and wet in macro and micro scale habitable space And general changes in consumer materials residential structures in rural areas, the use of natural energy role in natural ventilation by not using energy artifact(Cooling and heating) is not possible and the combination of the two systems, natural and artificial energy is not inevitable, even in native settlements.
Research purposes
I. Clear analysis of how the formation of a native settlement on the centrality of body structure and climate
II. Assessment components and sub a native settlement in the description of the concepts of sustainable Sachs
III. Analysis of large-scale example of architecture in warm and cold seasons the energy simulation software

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In this paper, an approximate solution using layer-wise theory for the vibration analysis of rotating laminated cylindrical shells with ring and stringer stiffeners under axial load and pressure is presented. The cylindrical shells are stiffened with uniform interval and it is assumed that the stiffeners have the same material and geometric properties and cylindrical shell reinforced by outer stiffeners while stiffeners are treated as discrete elements. The equations of motion are derived by the Hamilton’s principle. In deriving the governing equations three-dimensional elasticity theory are used and the study includes the effects of the Coriolis and centrifugal accelerations and the initial hoop tension. The layer-wise theory is used to discretize the equations of motion and the related boundary conditions through the thickness of the shells. The edges of the shell are restrained by simply supported boundary conditions. The presented results are compared with those available in the literature and also with the FE results and excellent agreement is observed. Finally, the results obtained include the relationship between frequency characteristics of stiffened cylindrical shell and different geometry of stiffeners, stiffener type, rotating velocities, amplitude of pressure and amplitude of axial load.

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These days biosensors have worthy applications in different fields such as biomedicine, disease diagnosis, treatment monitoring, various aspects of the environment, food control, drug production, and assorted sides of medical science. Recently, different types of biosensors such as enzyme biosensors, immune, tissue, DNA, and thermal biosensors have been studied precisely by some research groups. These biosensors have many advantages such as simplicity in implementation, very high sensitivity, automatic performance, intrinsic and natural small size. Another valuable benefit of biosensors is that their high-affinity paring with biomolecules allows sensitive (high-sensitivity) and selective detection from a wide range of analytes. Artificial intelligence (AI) due to its high potency, if combined with biotechnology, like biosensors, can be effective in accurate prediction, diagnosis and treatment of some diseases, including cancer. Today, Machine learning (ML) as one of the branches of AI has become a beneficial tool in analyzing and categorizing obtained data from biosensors for bioanalysis. Using ML algorithms automates the complicated processes of extraction, processing, and assaying data achieved from biosensors. This article is a review for introducing and survey of various biosensors, their applications, and ways to apply them, focusing on cancer and Covid19 which are important diseases in the world obtained from previous studies, as a summary and providing information for researchers which working in this field.
 

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Chondroitinase ABCI is a bacterial lyase that degrades glycosaminoglycans and promotes axonal growth and functional improvement. However the stability and maintenance of this enzyme is very limited. One of the strategies to overcome this limitation is to immobilize the enzyme. In this research, chondroitinase ABCI (cABCI) from Proteus Vulgaris was immobilized on hydroxyapatite nanoparticles. Hydroxyapatite is a non-toxic ceramic biomaterial that has a high surface area, which is beneficial for loading a large amount of enzyme. Therefore, to increase the stability of chondroitinase ABCI, immobilization on hydroxyapatite nanoparticles for 4 hours through physical adsorption in  phosphate buffer pH 5, 6.8, and 8 at 4^◦C was carried out. Enzyme immobilization on hydroxyapatite nanoparticles was then confirmed by field emission gun-scanning electron microscopy and UV-spectroscopy, before and after immobilization. Then, in order to obtain the optimal pH and temperature, the activity of the nanosystem was investigated at three pH and temperatures (4°C, 25°C, and 37°C). Results revealed higher activity at pH 5 and temperature 4 ◦C than the other pH and temperatures for the nanosystem. Based on the obtained results, which show the stability of the nanosystem at all three temperatures compared to the free enzyme, this nanosystem could be a potential candidate for clinical applications in future.

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Ensuring food security in developing countries is highly challenging due to low productivity of the agriculture sector, degradation of natural resources, crop losses, less value addition, and high population growth. therefore, researchers are striving to adopt newer technologies to increase the supply of agricultural products. one of these technologies is nanotechnology. Nanotechnology is the science of producing, manufacturing and using materials at the atomic and molecular levels and it can transform various industries, including the agricultural industry, with the help of new tools. Nanotechnology By using new materials such as nanofertilizers, nanoherbicides, nanopesticides, etc., strengthens the soil and increases the growth of plants and with the help of new tools such as nano-sensors and intelligent delivery systems, identifies pathogenes in plants.  For these reasons nanotechnology can be a promising way to increase the productivity of agricultural products.­­­

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In unmanned aerial vehicle (UAV) classes, the control of quadrotor has attracted many researchers from around the world in recent years. In this type of rotary wing, it is attempted to achieve stability in hover and motion flight modes using the forces, produced by propellers. Quadrotor has nonlinear and time-varying behavior and the aerodynamic forces almost always disturb it. In near the ground, the wake of quadrotor interacting with the ground surface causes perturbation to the flow near the blades and frame. These perturbations have significant effect on quality and stability of flight. Most of the related researches were only studied hover and landing operation and the ground effect was considered as constant coefficient in dynamic equations. In this paper, a comprehensive nonlinear model is developed for variety modes of quadrotor flight in near the ground in space state, and the ground effect is as function of state variables in equation. Then, according to the proposed model, the PID controller is designed and the effect of the ground effect on controller performance is investigated. The results of simulation indicate that, the flight stability and trajectory tracking have improved significantly by using of the model and designed controller.