The aim of this study was to evaluate the effects of feed supplemented with different levels of Selenium Nanoparticles (SeN) on growth, survival, and biochemical indices of
Acanthopagrus latus. Yellow-tail seabream fish with a mean weight of 52±3 gwasfed with four experimental diets containing 0, 0.5, 1, and 2 mg kg
-1 SeN for 8 weeks. At the end of the experiment, the fish fed 0.5 mg kg
-1 SeN showed a significant improvement of weight gain compared to the control (P< 0.05). Specific growth rate, feed conversion ratio, and survival were not significantly different between treatments (
P> 0.05). The lowest activity of alkaline phosphatase, alanine amino transferase, creatinine phosphokinase and cholesterol were observed in 0.5 mg kg
-1 SeN treatment, which was significantly lower than the control (P< 0.05). Although aspartate amino transferase, lactate dehydrogenase, triglyceride and creatinine were not significantly different among experimental treatments (P> 0.05), total protein and albumin levels were significantly increased in the 1 and 2 mg kg
-1 SeN treatments compared to the control group. The highest level of globulin was observed in the 2 mg kg
-1 SeN treatment. According to the results, the addition of 0.5 mg kg
-1 SeN to fish feed could improve growth and biochemical parameters.
