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Aims: Infectious diseases are among the most serious diseases that may lead to death in many parts of the world. This study was conducted to investigate the main causes of mortality among patients hospitalized in the infectious ward and respiratory ICU of Sina hospital in Hamadan.
Materials & Methods: The medical records of patients hospitalized from March 2012 to March 2017 in the infectious ward and respiratory ICU were investigated, those not surviving during the hospitalization.
Findings: A total of 593 medical records of patients were reviewed, of which 534 cases were enrolled in this study. Among which, 426 (79.8 %) and 108 (20.2%)cases were related to patients hospitalized in the respiratory ICU and infectious ward, respectively The mortality rate during 2012 to 2016 was calculated as follows: 4.69% in 2012, 6.31% in 2013, 4.68% in 2014, 5.2% in 2015, and 5.8% in 2016. This study results showed that the most common causes of mortality were sepsis (44.4%) in the respiratory ICU and pneumonia (25.3%) in the infectious ward. The highest rates of case fatality were related to sepsis (237cases, 48.2%) and pulmonary embolism (15 cases, 44.1%).
Conclusions: The present study findings showed that sepsis and pneumonia were the most common causes of death among patients hospitalized in the infectious diseases ward and respiratory ICU; also, sepsis and pulmonary embolism accounted for the highest case fatality rates.

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Skeletal muscles simulation remains a controversial topic as a result of its complex anatomical structure and mechanical characteristics such as nonlinear material properties and loading conditions. Most of the current models in the literature for describing the constitutive equations of skeletal muscles are based on Hill's one-dimensional, three element model. In this paper a 3D constitutive model which is based on the hyper elastic behavior of skeletal muscle and energy function has been presented. By using the derivatives of such energy function for defining the Second Piola and Cauchy stresses, we able to describe the inactive behavior of skeleton muscles. The applied constitutive equations are an efficient generalization of Hamphury's model for the inactive behavior of skeletal muscle. In this paper using a 3D model, different modes of deformations of skeletal muscle such as simple tension, biaxial and shear tests has been investigated and material properties constants for each modes of deformation has been optimized by Genetic algorithm. Finally the results of the model simulations of each mode are compared with those obtained from experimental tests. Also, the model results are compared with the ones from two well- known hyper elastic Ogden and Mooney-Rivilin models in order to show the priority of the new developed 3D model to those aforementioned models has been shown.

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Silver Nanoparticles (AgNPs) are widely used in medical and pharmaceutical applications due to their antimicrobial properties. In this study, Ag-NPs were synthesized using Viola tricolor aqueous extract as a reducing and capping agent. The presence of synthesized Ag-NPs was first confirmed with UV-Visible, SEM, TEM, XRD, and FTIR analyses, and then their antimicrobial characteristics were studied based on the Minimum Inhibitory Concentration (MIC). The SEM analysis showed that the synthesized AgNPs were spherical in shape. The particle size histogram revealed that the average particle size of the AgNPs was 49.45 nm. Findings from the FTIR and UV-Vis spectra showed the successful formation of Ag-NPs because the functional groups involved in the synthesis process and adsorption peaks were well developed. Furthermore, the Ag-NPs had a peak absorption at 420 nm in the spectrometry. MIC results showed the strong antimicrobial effects of the synthesized Ag-NPs. Results of the Minimum Bactericidal Concentration (MBC) revealed the dose-dependent cytotoxicity of the Ag-NPs. Nanoparticles could exert the inhibitory effect of DDPH free radicals in a dose-dependent manner. Methyl tetrazolium (MTT) results showed that silver nanoparticles had a dose-dependent cytotoxic effect and significantly reduced cell survival. The IC50 values for Ag-NPs and the extract were 11.83 and 204.4 μg mL^-1, respectively. This study showed a higher cytotoxic effect of the green synthesized nanoparticles on hepatocellular carcinoma cells than the extract. Consequently, the biosynthesis of Ag-NPs using aqueous extract of V. tricolor is clean, inexpensive, and has antibacterial, anticancer and antioxidant activities. Hence, it can be used as a drug candidate.

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Developing high-yielding varieties of sunflower as oilseed staple crops requires knowledge of physiological and molecular mechanisms involved in yield formation. Source strength, sink demand, and their interactions play crucial roles in the yield formation of sunflowers. The persistence of assimilate flux to the developing grains mainly determines sink demand. There was no information on the molecular mechanism for assimilate flux to the sink organ of sunflowers. To shed light on molecular events engaging in assimilate flux to sink organs, two experiments were carried out on five sunflower inbred lines differing in their grain yields. Source-related parameters (such as leaf biomass, area, and number) and sink-associated attributes (such as floret number at the first anthesis and capitulum biomass and diameter, in addition to changes in biomass of capitulum and stem, at the first anthesis with those at physiological maturity) were evaluated across all the inbred lines. The Invertase gene expression level was measured on the receptacle base of three inbred lines, showing discrepancies in the source, sink, and grain yield performances. While no significant correlation was found between source strength and sink demand with grain yield, the results showed that higher grain yield was likely attributed to the persistence of assimilate flux to the capitulum base during grain filling. This phenomenon is discussed to be due to higher Invertase activity in the receptacle base.

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The present research, using the qualitative method and analytical-descriptive method, aims to performance a comparative study and explain the foundations and examples of the civil responsibility of electricity supply institutions. The findings of this research show that the civil liability of the mentioned institutions in Iran and America in the stages of production and transmission is considered as "Sovereign Acts" and in the stage of distribution among subscribers and consumers is considered as "Employee Acts"; In addition, the civil liability of the electricity supplier entities is "Contractual and Non-Contractual" in nature, and both Iranian and American legal systems consider the civil liability of the electricity supplier entity in the production phase, which is a liability based on the contract; with the difference that the basis of responsibility is different in these two legal systems; As in Iranian law, this responsibility is based on "Fault" and claimable damages resulting from the violation of contractual obligations are subject to the specification of the parties, custom or law; But in American law, the basis for establishing the contractual liability of the aforementioned entities is "Pure Liability" or liability without fault, and the liability of these entities is established solely based on the breach of obligation; Therefore, in this legal system, as soon as a breach of contractual obligations is established, regardless of the reason for the breach or fault, the obligee is responsible for compensation. In the stage of electricity distribution, in Iran's legal system, it is possible to point out the responsibility resulting from the lack of care and maintenance of the facilities and equipment for the transmission and distribution of electricity to the subscribers, as well as the responsibility resulting from negligence and failure to take preventive measures, which is the factor of "Fault" Civil liability plays a fundamental and key role for the aforementioned supplier institutions; But in the American legal system, one can find very limited cases in which civil liability can be proposed for the mentioned institutions at this stage, and basically it is very difficult to establish civil liability at this stage, and this is due to the mechanisms that exist in this country in In order to comply with electricity transmission and distribution standards, division of responsibility and the involvement of consumers and subscribers in possible damages are applied.