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Background: In late December 2019, a new coronavirus called SARS-CoV-2, as the causative agent of COVID-19 (coronavirus disease 2019) pneumonia, began to spread from Wuhan, China. The SARS-CoV-2 virus is currently threatening the world’s public health and so far, no specific and effective treatment has been found for the disease. Due to the physiological changes in the body of pregnant women during pregnancy, the occurrence of infection in pregnant women could affect the health of both mother and her fetus. The present paper aimed to study the findings related to the effects of coronavirus on pregnant women and their fetuses during pregnancy, diagnostic methods, care protocols in pregnant women, and postpartum care.
Methods: The information included in this review was extracted from articles, published protocols, and valid statistics. In this study, articles indexed in Latin databases (PubMed, Google Scholar, Science Direct, Embase, Scopus), clinical protocols, and reports of reputable health organizations from January to august 2020 were reviewed using a combination of the following keywords: COVID-19, SARS-CoV-2, pregnant woman, and pregnancy.
Conclusion: Due to the global prevalence of this virus, protocols and health care should be applied for pregnant women in accordance with other people. It is also necessary to take preventive measures at the community level. In this regard, the management of pregnant women with COVID-19 infection is of particular importance during the pandemic period of the disease. However, more extensive studies are required to validate these principles. This review summarized the precautions that should be taken before and after delivery.

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Backgrounds: It is evident that the success of common cancer treatments is reduced due to limited drug access to tumor tissue, the drug toxicity intolerance in healthy cells, as well as the exposure of the immune system to the drug. Cancer stem cells are also a small population of tumor cells, which have different potentials for regeneration, proliferation, and differentiation and serve as a carcinogenic driving force. They are believed to play a key role in the onset, progression, drug resistance, recurrence of cancer, or metastasis. Although mesenchymal stem cells (MSC) have a slight ability to migrate toward the tumor, they could be considered as a cellular carrier for tumor targeting due to lack of recognition by the host immune system. Stem cells with their own ligands could effectively target cancer cells. One of the CD markers that exist on the surface of stem cells is CD44v6, which is considered as a homing receptor. Given that the expression level of stem cell markers is reduced during consecutive cultures in vitro environment; therefore, in the present study, stem cells were engineered using CD44 lentiviral vectors to more effectively improve the implantation and targeting of the colon cancer cell model.
Materials & Methods: In this study, the structure of the CD44 gene was designed in lentiviral vectors and transfected to the HEK293T cell line along with auxiliary plasmids PSPAX2 and PMDG2. The growth medium of virus-containing cells was collected at optimized intervals, and transduction into mice mesenchymal stem cells, injection into mice, and homing processes were traced.
Findings: Successful production of lentiviral vectors and proper expression of the corresponding factor after transduction were effective in improving the MSC homing in cancer cell.
Findings: According to these findings, it could be suggested that high expression of CD44v6 factor could be effective in improving the implantation process in cancer cells and targeting treatment.
 

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 Scheduling plays an important role in the development and success of the project; this has always been one of the main issues considered in operations and management science researches. Another reason for the focus of much research into it is the difficult nature of this problem. Therefore, special techniques and methods have been proposed to solve this problem. On the other hand, in order to intensify sanctions on foreign delaying projects, timely completion of projects has been accelerated. Therefore, attention to project robustness subject to project managements. In this article, a real issue is scheduled for a robust scheduling model of a refinery project. Since project scheduling has resource constraints such NP-Hard problems, simulated annealing algorithm was proposed to solve this problem. In order to validate the model, 4 problems with small size were chosen and the solutions obtained by the proposed algorithms were compared with the exact solution obtained by Lingo8 software. The results showed that the proposed algorithm is efficient and convergent to the optimal solution.

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In this study the effect of chickpea flour in three ranges of (0, 1.5 & 3%) and storage time in three ranges of (1, 11 & 21 days) on survival of lactobacillus paracasei and qualitative properties of fruit yogurt containing 15% apple puree was investigated using response surface method (RSM). The statistical analysis of the results showed that with increasing of chickpea flour up to 0.5%, lactobacillus paracasei viability increased but with increasing of flour more than this amount the bacterial count decreased significantly (P<0.05). The bacterial count decreased during storage (P<0.05). The addition of chickpea flour decreased pH, moisture content, syneresis and increased acidity, ash and apparent viscosity significantly (P<0.05). During storage pH and moisture content decreased and apparent viscosity increased (P<0.05). In sensorial evaluation of samples the addition of chickpea flour decreased the flavor score and improved consistency score (P<0.05). In conclusion, using of 2.36% of chickpea flour and with storage period of 9 days was determined as optimum conditions.

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