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Rapid and sensitive diagnosis of breast cancer, especially in the early stages of its formation, is very important. One of the methods of detecting cancer cells is the use of electrochemical sensors. Here, a new nanocomposite including an organic metal framework and silver nanoclusters are used. The resulting nanocomposite can be used as a scaffold to attach antibodies for the detection of HER2-positive cells. In the final nanocomposite structure, silver nanoclusters are placed in the internal cavities of the metal-organic framework, leading to strong electron transport, good biocompatibility, and high electrochemical activity. Our results showed that the designed electrochemical sensor has a high sensitivity in identifying HER2 positive cells, with a detection limit of 3 cells and a linear range of 100 to 5000 cells/ml. Also, the investigations showed that the introduced sensor has stability, good selectivity and acceptable application. The proposed strategy for the development of sensors based on metal-organic frameworks provides a promising approach for early detection of cancer markers and living cancer cells.
 

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Magnetic nanoparticles (MNPs) have emerged as contrast agents in magnetic resonance imaging (MRI) and metal-organic frameworks (MOFs) due to their high porosity and adjustable structure, serving as drug carriers and new contrast agents in biomedicine. Designing efficient nanoplatforms that leverage the combined properties of both MNPs and MOFs is of great importance.
In this study, we introduce a simple in-situ synthesis method for a mesopore core-shell nanocomposite structure of MOF@Cu-ferrite. Initially, Cu-ferrite nanoparticles were synthesized using a hydrothermal method. Subsequently, the addition of fumaric acid to the Cu-ferrite nanoparticles activated the F0 component, inducing MOF nucleation. As a result, the Cu-ferrite core was gradually covered with a crystalline MOF shell, forming the MOF@Cu-ferrite structure. The MOF@Cu-ferrite nanocomposite is characterized by high porosity, numerous accessible surface functional sites, good crystalline stability, low toxicity of copper, excellent water dispersion, high magnetic properties, and cost-effectiveness. This study investigates the effect of the MOF@Cu-ferrite nanocomposite on the MRI signal intensity. T2-weighted images were obtained using MRI scanner at various iron concentrations of the magnetic nanocomposite, showing a significant change in signal intensity with increasing iron concentration. The transverse relaxivity rate (r2) for different iron concentrations was found to be 504.7 mM^-1s^-1. The results showed that Cu-ferrite magnetic nanoparticles coated with MOF have significant potential as negative contrast agents in MRI, reducing T2 relaxation time and improve contrast intensity in MR images.

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The lack of accessibility of high quality materials and the increased costs associated with the use of these materials will finally demand engineers to use local soils. In such cases, ground improvement performed reasonably in many conditions. Ground improvement can be defined as the procedure of increasing shear strength parameters and decreasing the permeability and compressibility of the soil. Different methods can be used to improve the geotechnical properties of the problematic soils such as loose sand that one of them is using additives. The stabilization of soils with cement is an attractive technique due to economic and environmental issues and avoiding the use of borrow materials from elsewhere. Cementation of sand results in increased brittle behavior as peak compression strength increases. The compressive strength of artificially cemented soils has been studied in the past by several investigators.A number of studies have also reported on the influence fiber, glass, fly ash, silica fume and nono particle on the mechanical behavior of cemented sands .However, to the author’s knowledge, there has been a little effort devoted to the research on the use of pozzolans such as natural zeolite as an addictive material to the cemented sands. Natural zeolite, an extender, has been investigated for use as cement and concrete improver by some researchers.
It is widely known and well emphasized that the cemented sand is one of economic and environmental topics in soil stabilization. In some instances, a blend of sand, cement and other materials such as fiber, glass, nano particle and zeolite can commercially available and effectively used in soil stabilization in road construction. In this investigation, zeolite and its effect on unconfined compression studied as one of addictive material to cement. Therefore, cilinopiolite kind of zeolite, Neka cement type II and Babolsar sand are used. A total number of 144 unconfined compression tests were carried out on 24 combination type of cement and zeolite include different cement percentages 2, 4, 6 and 8 percent of total dry weight of samples and replacement percent’s of 0, 10, 30, 50, 70 and 90 zeolite with cement based on 50,70 and 85% relative densities in7 and 28 days curing times. Results show that in 28 day curing time, by replacement percentage of 30 zeolite material by cement, the unconfined strength increased 20 to80% in comparison with cemented samples by increasing shear strain. For higher cement content and less compacted blends, these improvement rates are more. At the end, a power function fits presented to relate unconfined compressive strength (UCS) and zeolite-cement-soil parameters (porosity (n) and voids/ polynomial model of cement and zeolite voids).It is widely known and well emphasized that the cemented sand is one of economic and environmental topics in soil stabilization. In some instances, a blend of sand, cement and other materials such as fiber, glass, nano particle and zeolite can commercially available and effectively used in soil stabilization in road construction. In this investigation, zeolite and its effect on unconfined compression studied as one of addictive material to cement. Therefore, cilinopiolite kind of zeolite, Neka cement type II and Babolsar sand are used. A total number of 144 unconfined compression tests were carried out on 24 combination type of cement and zeolite include different cement percentages 2, 4, 6 and 8 percent of total dry weight of samples and replacement percent’s of 0, 10, 30, 50, 70 and 90 zeolite with cement based on 50,70 and 85% relative densities in7 and 28 days curing times. Results show that in 28 day curing time, by replacement percentage of 30 zeolite material by cement, the unconfined strength increased 20 to80% in comparison with cemented samples by increasing shear strain. For higher cement content and less compacted blends, these improvement rates are more. At the end, a power function fits presented to relate unconfined compressive strength (UCS) and zeolite-cement-soil parameters (porosity (n) and voids/ polynomial model of cement and zeolite voids).

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