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Backgrounds: SARS-COV-2 infection is not always correlated with protection. Antibody seroprevalence in unvaccinated individuals, which is usually measured by N-specific antibodies, is not necessarily correlated with protection, while antibodies against S protein show a better correlation with protection due to its neutralizing epitopes. In this study, we tried to improve our conception of the hidden perspective of SARS-COV-2 in epidemiological reports and investigate anti-S antibody prevalence among anti-N antibody-positive asymptomatic and mildly symptomatic patients.
Materials & Methods: Blood samples were collected from asymptomatic or mildly symptomatic volunteer participants and symptomatic hospitalized patients with negative PCR results from May 30 to June 17, 2020. Detection of SARS-COV-2 antibodies was done using an ELISA kit targeting N or S protein.
Findings: Totally, 716 samples from volunteer participants and 81 samples from symptomatic hospitalized patients with negative PCR results were evaluated. The test performance-adjusted seroprevalence (95% CI) of SARS-COV-2 antibody was 17.3% (8.8-25.8%) for anti-N IgG in volunteers and 25.5% (12.8-39.7%) for anti-N and anti-S IgM in hospitalized patients. Among anti-N IgG positive infected individuals, 49.2% (21.4 and 78.8%) were anti-S antibody positive.
Conclusion: The results showed that SARS-COV-2 infection sometimes occurs in individuals without symptoms or with mild symptoms, but in more than half of them, the produced antibody is not protective. The findings of hospitalized patients showed that the combination of IgM assay with real-time PCR improved the disease diagnosis by more than 25% in cases with negative molecular test results.

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Hirmand River is originated from Afghanistan and the people's life in Sistan is depended on it. The increasing and reduction of Hirmand water flowing toward Sistan (Iran) from one hundred years ago have already caused problems in political relation between Iran and Afghanistan in local and national levels. This research wants to find the increasing and reduction reasons of Hirmand water toward Sistan and effect of it on political relationship between Iran and Afghanistan .Drought and reduction of flowing water from Afghanistan have caused reduction in water flowing toward Sistan and also caused water crises in this area. However , over past one hundred years the Afghanis separated various canals from Hirmand and built many dams over it , have consumed a large amount of water and also the rate of flowing water toward Sistan has reduced ..

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The present Research has surveyed the foreign policy of the Islamic Republic of Iran vis-à-vis the Republic of Azerbaijan. Based on some of the most important geographical and geopolitical realities that exist between the two states, by presenting one main question and two hypotheses, used as guide into a thorough geopolitical assessment of the issue. Based on the findings, we come to this conclusion that the none-cordial disposition of the Republic of Azerbaijan towards Iran, and some of the uncharted pasturings and unspecified strategies by the Islamic Republic of Iran render ineffective so many positively positoned areas of common geographical and/or geopolitical interests such as territorial contiguity, common religious tendency (both Shiite), common ethnicity, common economic interests (agricultural and irrigation possibilities), common cultural and historical backgrounds. Unfortunately, the continued policies between the two states have further made all these possibilities to render ineffective. The main outcome of the research shows that some of the issue are resultant from a suspected nationalistic disposition on the part of the Iranians; and similarly, a persistent attitude of none cordiality from the Azeris. Moreover, the Republic of Azerbaijan has yet to present a logical and pragmatic reason to explain its negative diplomatic strategy against the Islamic Republic of Iran That could justify its distrustful policy towards iran. The research consequently has proposed the following general aims and strategies to be implemented in Iran’s faring policy towards the Republic of Azerbaijan: General aim: the faring policy of the Islamic Republic of Iran in relation to the Republic of Azerbaijan is determined by geographical and geopolitical realities that exist between the two states. Strategy: to develop mutual relations based on the need for neighborly dispositions, to understand the geopolitical dictates of time and space, common national interests and aims,economic cooperation,and to explore other avenues that would develop mutual trust in order to broaden cooperation between the two states.

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