---

Objective: Premature ovarian failure (POF) is one of the most important reproductive diseases in women under 40 years of age, which affects the quality of life and longevity of these people by causing short-term and long-term complications.
The incidence of POF is a chronic process that takes several years to develop. The patient went through stages such as premature ovarian insufficiency (POI) and decreased ovarian reserve (DOR), in the early stages of the disease decreased ovarian function efficiency (POI) and then with further progression of the disease, the patient decreased ovarian reserve and further reduce their performance. As the disease progresses, the person eventually develops premature and complete ovarian failure, or POF studies have shown that many factors, including surgical trauma, autoimmune diseases, certain drugs, vaccines, and genetic factors, play a role. Genetic studies have shown that several genes are involved in the development of this disease. Part of the regulation of the expression of these genes is the responsibility of small genetic factors called miRNAs.
Materials and Methods: In the present study, bioinformatics information of miRNAs involved in this disease was investigated. For this purpose, genetic databases such as UCSC, NCBI, KEGG, MIRBASE, TARGET SCAN, STRING, etc. were used to access the genes involved in this disease, structural and functional communication, messaging pathways and regulatory miRNA.
Results and Conclusion: The results of this study indicate that three factors, miRNA-187, miRNA-33b and miRNA-33a, are very effective in the development and progression of this disease.

---

In this paper, the process of joining Ti-3Al-2.5V titanium alloy thin sheets by means of micro-plasma arc welding (MPAW) is reported. An experimental set-up was developed using traditional gas tungsten arc welding apparatus and a home-built torch for butt welding of coupon specimens. The specimens were welded under controlled welding parameters, such as voltage, current, travel speed and shielding gas flow rate. An appropriate set of parameters for MPAW process was examined by mechanical properties tests and microstructure characterization. Mechanical tests including tensile test, bending test and micro-hardness evaluation across the weld line generally show that if suitable welding parameters are used, the tensile strength of the welded specimen is well comparable with that of the base metal while its hardness increased at the fusion zone (FZ). The bending test revealed that using appropriate welding parameters, no crack or notch appeared at the welded joint. Fractography, X-ray diffraction and metallograpghy were also performed to study the microstructure evolution. SEM images of the fracture surface presented characteristics of ductile rupture. Studies on microstructure morphology of the specimens at the FZ and HAZ reveal occurrence of phase transformation from high temperature phase to acicular phase