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Showing 2 results for Hooshyar Chechaklou
Volume 10, Issue 3 (Summer 2024)
Abstract
Background: Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system. Toxoplasma gondii infection is one of the risk factors of MS. Knowing the correlation between T. gondii infection and MS could lead to a better understanding of the disease incidence. This study aimed to assess the correlation between T. gondii infection and the disease incidence in infected individuals.
Materials & Methods: Serum samples of 38 MS patients referring to the neurology clinic of Ghaem hospital in Mashhad in 2019 were analyzed by Pishtazteb commercial kit for anti-T. gondii IgG and IgM antibodies using enzyme-linked immunosorbent assay (ELISA). The obtained data were analyzed with SPSS software Version 20.
Findings: Among the 79 tested individuals, 22 were positive, and 57 were negative for anti-T. gondii IgG antibodies. Among the negative cases, 29 (50.9%) had MS, and 28 (49.1%) were controls. Among the positive cases, nine (40.9%) patients had MS, and the remaining 13 (59.1%) were controls. The frequency of IgG antibody in the case and control groups was not significantly different (p= .427). Anti-T. gondii IgM antibody was negative in all samples. There was no significant difference between the types of MS regarding the frequency of anti-T. gondii antibodies (p= .402).
Conclusion: No significant difference was found in the frequency of anti-T. gondii IgG antibodies between the two groups. However, further studies with larger sample sizes are recommended to gain a better understanding of the relationship between anti-T. gondii IgG antibody positivity and MS incidence
Volume 10, Issue 4 (Fall 2024)
Abstract
Background: Viral infections may play a significant role in the development of heart failure, especially in people with related cardiac conditions such as myocarditis. Hepatitis B and D viruses (HBV-HDV) are potentially fatal liver infections. This study examined the influence of metabolic syndrome and its associated disorders.
Materials & Methods: This cross-sectional study investigated hepatitis D antibody and hepatitis B surface antigen (HBsAg) in 239 people aged 35 to 65 years in Mashhad, Khorasan Razavi Province, Iran in 2018-2019. There were two study groups: those with cardiovascular diseases (CVD) and healthy individuals. Serum samples of all subjects in both groups were examined using enzyme-linked immunosorbent assay (ELISA).
Findings: HDV infection was detected in none of the study groups. Only one patient (0.8%) in the case group tested positive for HBsAg. The average LDL (low-density lipoprotein) (p= .8) and cholesterol (p= .3) levels in terms of lipid profiles were similar in both groups. Although the mean high-density lipoprotein (HDL) level in the patient group was lower, the mean triglyceride level in this group was higher than in the control group. Fasting blood sugar (FBS) (p= .009) and aspartate aminotransferase (AST) levels were significantly higher in CVD patients, while 59.3% of them exhibited metabolic syndrome.
Conclusion: This study results demonstrate no connection between HBV/HDV infection and cardiovascular diseases. The findings confirm that metabolic syndrome and hyperglycemia are underlying factors in cardiovascular diseases. Changes in HDL and triglyceride levels could impact cardiovascular diseases more than other lipids.
