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Nowadays, the seismic performance-based design of structures has been widely noticed by the engineering community. So, different methods for performance-based design have been presented by different researchers. This attitude has been included in the design code and regulations for seismic design of new buildings and retrofit of existing buildings. The FEMA P-58 performance-based design method presented by the Pacific Earthquake Engineering Research (PEER) can quantify the consequences related to the seismic response of buildings. Therefore, using this method, the seismic performance of buildings can be directly evaluated. In addition, this performance-based design method can define simpler criteria such as repair cost, repair time, and casualties for seismic evaluation and decision-making process. The method is based on considering different sources of uncertainty in earthquake input and its intensity, structural response, associated damage, and repair cost, using the concepts of conditional probability and total probability theorem. In this method, the building is designed in such a way that it meets the expected and predetermined performance level in a specific level of seismic excitation. Since the performance levels of the building are determined based on the amount of damage caused to structural and non-structural members, one of the practical and effective ways to evaluate performance is to estimate the building repair cost. In the approach presented in FEMA P-58, the repair cost is defined in a probabilistic approach, as the cost needed to restore the damaged parts to their original state in the form of expected annual loss. In this research, first, three 4-, 12-, and 20-story office buildings with the lateral force resisting system of reinforced concrete special moment frames were selected in a high seismic risk area. Then, the nonlinear model of structures was provided in OpenSEES software. In order to reduce the computational cost and analysis time, the single-bay Substitute Frame model was used to simplify the multi-bay reinforced concrete moment frames. All four structures were subjected to Incremental Dynamic Analysis (IDA) for 30 earthquake records. A probabilistic relationship between the spectral acceleration of the earthquake and the main damage parameter (i.e. the inter-story drift), as well as the collapse fragility curve, was obtained. Then, the repair cost including the cost of repairing structural members as well as beams and columns, the cost of repairing non-structural members as well as partition and curtain walls, and the cost of replacing collapsed structures was calculated as expected annual loss. The results show that the repair costs at the Design-Based Earthquake (DBE) for 4-, 12-, and 20-story buildings are 3%, 2.5%, and 10% of the building replacement cost and at Maximum Credible Earthquake (MCE) are 22%, 23%, and 38% of the building replacement cost, respectively. In addition, in short buildings, most of the cost is caused by repairing structural and non-structural members, and in tall buildings, most of the cost is caused by replacing collapsed or severely damaged structures. Considering two nonstructural elements (i.e. partition and curtain walls) in repair cost, the analysis results show that the cost of repairing structural elements is more than the cost of repairing non-structural elements.

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Backgrounds: The primary goal of this study was to identify the potential association between COVID-19 prognosis and demographic and clinical features, underlying diseases, and drug and supplement use in patients admitted to Amir al-Momenin hospital in Zabol.

Materials & Methods: This retrospective study surveyed the electronic health records of 848 COVID-19 patients hospitalized in a tertiary referral hospital in southeastern Iran from the beginning of the COVID-19 outbreak until the end of February 2021. Univariate and multiple analytical tests including unconditional and penalized logistic regressions were used for statistical analysis.

Findings: Out of a total of 848 patients, 371 (43.75%) patients were female, and 477 (56.25%) patients were male. Age, underlying pulmonary and cardiovascular diseases, and loss of consciousness predicted a higher mortality rate. On the contrary, a negative chest X-ray was associated with a lower risk of death.

Conclusion: Identifying predisposing factors of mortality in COVID-19 patients will help physicians provide more intensive care to those at higher risk of death by classifying patients based on risk factors and underlying diseases.

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Critical realism,as a branch of the literary school of realism,seeks to convey objective and accurate experiences of reality to the reader by looking at the social problems of man in the new age,and to criticize the prevailing situation in society with a reformist attitude. Samuel Shimon In his first novel,“An Iraqi in Paris”,was able to gain a special place in the field of fiction in Arabic literature;Reza Ghasemi is one of the most prominent novelists of Persian literature that wrote the novel“Nocturnal Harmony”.Both novels reflect the realities of their society and the phenomenon of migration.The purpose of this study is investigate the harmful challenges of the migration phenomenon.In this research,by examining the components of immigration literature from the perspective of critical realism based on description and analysis in the context of the American comparative school, two novels are examined.The results of the research show:Doubt in the basis of insider culture and cultural contradiction in the novel"Nocturnal Harmony"is more prominent than the novel"An Iraqi in Paris" but this is manifested in both novels in the form of alienation.In both novels, critically reviewing the past,while criticizing the political and social conditions prevailing in their society,the way of teaching some religious and cultural teachings has also been criticized.The challenges of immigration are manifested in both novels in the form of disappearance,identity crisis, homelessness and insecurity,but the author has a positive view of the future in the novel"An Iraqi in Paris",but in the novel" Nocturnal Harmony"the authorchr('39')s view is hopeless.

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Background: Infectious agents are considered as one of the possible etiological factors of systemic lupus erythematosus (SLE). It has been suggested that torque teno virus (TTV) may trigger autoimmune disorders, but few studies have been conducted on the relationship between this virus and autoimmune diseases, especially SLE. The present study aimed to evaluate the association between TTV frequency and SLE.
Materials & Methods: Serum samples were collected from a total of 116 participants, including 58 healthy people and 58 SLE patients who referred to the rheumatology clinic of Shahid-Beheshti hospital in Kashan, Iran from January 2020 to January 2021. After the extraction of viral DNA from the samples, a nested PCR test was performed using specific primers to detect TTV.
Findings: TTV was detected in 43 SLE patients (74.1%, 95% CI: 63.4-86.2) and 33 healthy individuals (56.9%, 95% CI: 44.1-69.0). A significant correlation was found between SLE and the presence of TTV (r= .32, p= .03). There was no correlation between the presence of TTV and musculoskeletal involvements, skin lesions, renal manifestations, and hematological manifestations (r< .05, p> .05). TTV was detected more frequently in patients with active lupus than in patients with quiescent disease, and this difference was significant (p= .048).
Conclusion: A significant association between TTV and SLE was observed in the present study; however, further studies are needed to investigate the role of TTV in the pathogenesis and clinical course of SLE.

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According to theresearchersfocused onthe roleof bread in thenational economyandtheuse ofnaturaladditivesto reducestalingrateand improvethe quantitative and qualitativeproperties ofstrategic products, So The aim of thisstudy was to investigatethe effect ofdifferent levels ofwatermelon(0, 1, 2, 4, 8 and 16%) on dough farinographypropertiesandmoisture content, specific volume, porosity andfirmness of semi volume Barbari bread. Inthis study, Image J software was used for porosity measurement. The resultsshowed thatwith the increasing ofwatermelonin the bread formulation, water absorption anddegree of softening increased butthe amount of dough stability decreased. While the mostdoughdevelopment timewas observedinsamples containing2% water melon. Also theresultsshowed thatthemelon water as a natural additive canincreases the amountof moisture content,porosity andspecific volumeanddecreased firmnessoftexture. So the highest moisture, specific volume andporosity were observed in ofthesamplescontainedrespectively16, 4and8% water melon. It should be notedthatsamples containing4% water melonhadthe lowestfirmness.  

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Aims: Tehran, as the capital of Islamic Iran, has a strong and valuable history in the modern period. The formation of new Tehran in less than three centuries ago and its dramatic changes in one and half century have created many problems for it. The most important identified challenge is the need to review Tehran's contemporary heritage, to materialize Islamic Iranian urban identity.

Methods: The research has a qualitative approach, which is known as "meta-analysis". The research technique is the analysis of documents through which the research examines the subject literature and upstream documents. Relying on "complete research" and "theoretical saturation" has given special validity to the research results.

Findings: The results of the research refer to ten concepts that are possible to recognize the modern identity of the city of Tehran, and redesign the Iranian Islamic identity of the city of Tehran through them. Things like 1- street, 2- urban open space, 3- religious places, 4- city geometry, 5- urban neighborhoods, 6- intermediate space, 7- cultural space in the city, 8- residence, 9- urban squares and 10- Education and educational spaces.

Conclusion: The results of the research emphasize the importance of "urban identification", "popularization" and "intelligence" as the three pillars of Iranian Islamic identity in the field of tasks and missions of Tehran City Beautification Organization; The issue that is needed to realize the vision of "Tehran; The metropolis is the model of the Islamic world" and its various dimensions are necessary and necessary.
 

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The aim of study it was carried out survey investigation of consumer attitudes toward organic agriculture. The study was a kind of applied and descriptive –correlational method. The research population was consumers of agricultural products in Alborz Province. Sample size was determine by Cochran's formula (n= 250). Proportional stratified random sampling method was used. Data was collected through an instrument that developed by researcher. Validity estimated by a panel of experts in University and Agriculture experts’ of jihad-e- keshavarzi department of Karaj city. Reliability was conducted by a Pilot test and Cronbach’s alpha coefficient assumed (0/75) which show its suit for research conduct. Data analysis was performed using SPSS software package. Research findings show that there is a significant difference between responces in diploma and graduate & post graduted level at the 0.05 level. Also there is positive relation between consume obstacle and factors affecting to use of organice agriculture with responcendents attitude.  

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  Quality and shelf life of bread as a main diet has the great importance on health and the national economy. So the aim of this study was to investigate the effect of water, melon water, oil, cow milk and soy milk as a glazing component of baguettes on the moisture content, specific volume, texture, crust color and overall acceptance of final product. In this study, Image J software was used for crust color measurement. Based on results, the samples have melon water, cow's milk and soy milk glaze had the highest moisture content. However, the samples containing water and water melon glaze had the highest specific volume. The results clearly showed that the samples were coating by water and melon water had the lowest firmness respectively in 2 and 72hr after baking. This indicates that melon water as a coating agent is better for preserving moisture and to retard the staling. In addition the highest amount of L* value and a* value and overall acceptance score in organoleptic evaluation were observed in the two samples coating by melon water and cow's milk. In general we can say that glazing is one of the techniques that are simple, low-cost addition to being a great role in maintaining and even improving the quantity and quality of bread. Also according to the results of this study, melon water, with its unique function as a new glaze in bakery industry is introduced.

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Cake is one of the most popular products in baking industry and consumption due to the relatively high presence in oil field products and the risk of hypercholesterolemia is limited to a specific group of people. Therefore, in this study a complete melon seeds flour at levels 5, 10, 15 and 20% due to lower cholesterol and unsaturated fatty acids, high-fat alternative to the original formulation of oil cake and the moisture content, specific volume, porosity, texture, crust color and overall acceptability of the samples produced were evaluated. The results showed that the addition of more than 10% melon flour reduces the amount of moisture and L* value. However, the specific volume and porosity of 10% melon seed flour with control samples showed no significant difference (P<0.05). Also the results clearly showed that the samples containing 10 and 15% melon seed flour and control sample had a similar texture. On the other hand, increasing the amount of melon seed flour in the formulation of oil cake increase the b* value of the samples. The sensory evaluation of samples containing 10% of melon seed flour as the best example, along with control samples (samples containing oil) were introduced. Thus, 10% of melon seed flour can maintain the quantity and quality of product and it’s a suitable substitute for oil in oilcake formulation.

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One of the most important issues in arch dam design, is optimum shape design of the dam body in such a way that both safety and economical constraints could be satisfied. The aim of this research is the introduction of some patterns for optimum arch dam shape in seismic zones and the identification of the optimum shape trends in proportion to physical and geometrical parameters of each specific site. Method of research includes parametric and statistical calculations on several arch dam sites samples. Thus optimization procedures are performed on dams with different heights, canyon widths, canyon shape types (V-shape or U-shape), and foundation moduli of deformation. Studying the resulting optimized arch dams shapes, certain trends of design variables is deduced in order to achieve optimum shape of the dam body when site specification changes. These trends are showed in graph forms. Resulting rules can be used as arch dam design guidline. One of the most important results of this study is the increasing trend in the thickness design variables in the central cantilever and abutments with the increase of the foundation modulus of elasticity. These rules can be used as guidelines for dam shape design. One of the most important issues in arch dam design, is optimum shape design of the dam body in such a way that both safety and economical constraints could be satisfied. The aim of this research is the introduction of some patterns for optimum arch dam shape in seismic zones and the identification of the optimum shape trends in proportion to physical and geometrical parameters of each specific site. Method of research includes parametric and statistical calculations on several arch dam sites samples. Thus optimization procedures are performed on dams with different heights, canyon widths, canyon shape types (V-shape or U-shape), and foundation moduli of deformation. Studying the resulting optimized arch dams shapes, certain trends of design variables is deduced in order to achieve optimum shape of the dam body when site specification changes. These trends are showed in graph forms. Resulting rules can be used as arch dam design guidline. One of the most important results of this study is the increasing trend in the thickness design variables in the central cantilever and abutments with the increase of the foundation modulus of elasticity. These rules can be used as guidelines for dam shape design. One of the most important issues in arch dam design, is optimum shape design of the dam body in such a way that both safety and economical constraints could be satisfied. The aim of this research is the introduction of some patterns for optimum arch dam shape in seismic zones and the identification of the optimum shape trends in proportion to physical and geometrical parameters of each specific site.

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Employing of complex surfaces in different industries such as aerospace and die and mold is increasing. For milling of such surfaces, considering factors such as strategies and machining parameters which affect the machinability is necessary. The objective of this study is to investigate the effect of different strategies and machining parameters on microhardness of a typical curved surface (convex) of stainless steel 1.4903. The cutting tool used in this study was ball nose end mill coated TiN and the strategies employed were Raster, 3D-offset, Spiral and radial. Design of experiments was done using Taguchi method. The input parameters were cutting speed, feed rate and step over. After conducting experiments, surface layers hardness of milled samples were measured. The results showed that various tool paths have different influence on microhardness of milled surfaces. Regardless of cutting condition, surface hardness after machining in all strategies was more than the primary hardness of the workpiece material. Spiral strategy provided the most hardness and radial strategy the least hardness. In addition, increasing the feed rate, cutting speed and step over, rised surface hardness and step over had least influence on hardness. The most hardness magnitude was reported in cutting speed of 180 m/min, feed rate of 0.18 mm/tooth and step over of 0.7 mm which shows 56 % of increase.

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In this study germinated quinoa flour in five levels (0, 5, 10, and 15%) was replaced by part of flour in gluten-free pan bread formulation. For this purpose, protein, moisture, specific volume, porosity, firmness (1 and 72 hours after baking) and overall acceptability were evaluated. Protein and moisture were increased by increasing of germinated quinoa flour in the formulation. The samples containing 10 % germinated quinoa flour had the highest specific volume and overall acceptability score and the lowest firmness after 1 and 72 hours after baking. Also, the result indicated the samples containing 10 and 15 % germinated quinoa flour had the highest porosity.
 

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Abstract
Ovarian cancer is one of the deadliest cancers in women causing abnormal cancerous cells that can spread and metastasize to other parts of the body. Secondary metabolites are highly variable in terms of structural and chemical properties and they are very important for plants survival. In this study, the extracts of two plants using three different solvents (water, ethanol 80% and methanol 80%) and water bath extraction method were obtained. phenolic compounds of extracts were determined by Folin Sioculto method. DPPH (2, 2-Diphenyl-1-picrylhydrazyl) and FRAP (Ferric reducing ability of plasma) methods were performed for determination of antioxidant properties. The amount of phenolic compounds in two plants was higher in 80% methanol solvent and the most antioxidant activities were observed in water solvent of extracts. Water solvent had the highest antioxidant activity and was selected to investigate the anti-cancer properties of extracts on ovarian cancer cells. Water extract of Ocimum basilicum within72 hours had the highest cytotoxic effect with an IC50 value of 1.105 ± 0.001 mg / ml. In study of antimicrobial activity by disc diffusion method, the highest antibacterial properties were only in ethanol extracts of two plants. In the measurement of MIC and MBC, ethanol and methanol extracts of Ocimum basilicum and water and ethanol extracts in Imatiens walleriana had the most inhibitory and bactericide effects.
 

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Many people limit their consumption of fried foods, including donuts. On the other hand, the consumers are looking for the functional food that contains natural resources. Also, the aim of this research was production of low-fat fictional of doughnut. Fennel powder (0, 1.5 and 3 %) and Fenugreek gum (0, 0.25 and 0.5%) were used in doughnut formula and total phenol, antioxidant, moisture, specific volume, porosity, texture (after 2 hours and 3 days) and sensory properties were examined.  The result showed Fennel powder increased total phenol and antioxidant of doughnut. Fenugreek gum was more effective to protect of moisture during 3 days. The samples containing 0.25 gum were the lowest firmness and the highest specific volume, porosity and L^*. The samples containing 0.25 and 0.50 gum had the same texture after 3 days. These samples were more softness than control. The finding showed the samples containing more than 0.25 % gum had the lowest a^* value. Finally the sample containing 1.5 % Fennel powder and 0.25% Fenugreek gum and the sample containing 3 % Fennel powder and 0.25% Fenugreek gum had the highest overall acceptability.

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Millet is a rich source of essential amino acids, vitamins and minerals. Also, Malva extract has phenolic compounds, antioxidant and antimicrobial properties. The purpose of the first part of this study was to investigate the effect of replacing part of wheat flour (0, 15, 30, 45 and 60%) with millet flour in cookies. In this section, technological characteristics (moisture, specific volume, porosity and texture) were evaluated. In the second part, in order to produce functional cookies, antioxidant and microbial activity and sensory properties of the selected sample in the first part were affected by 0, 100, 200, 300, 400 and 500 ppm of Malva extract. The results showed that the sample containing 15% of millet flour was the best cookie of the first part with the highest specific volume (1.73 cm3 / g), porosity (22.1%) and moisture (10.15%) and favorable texture (3.28 N) during two months of storage. The results of the second part showed the total phenol content increased from 1.6 to 53.5 mg / g by increasing Malva extract in the cookie formulation. However, the antioxidant activity of the sample containing 500 ppm of Malva extract increased from 12.1% to 61.2% compared to the control. The samples containing more than 200 ppm of Malva extract didn’t have mold and yeast during two months of storage. Also, the samples containing 100 to 300 ppm Malva extract obtained the highest color, texture, odor and taste score in the sensory evaluation. Therefore, samples containing 85% wheat flour, 15% millet flour and 300 ppm of Malva extract can be offered to the bakery industry as a functional cookie.

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The purpose of this study was to investigate the production of mayonnaise containing oleogel prepared based on sesame oil and organogelators of ethyl cellulose and carnauba wax and to evaluate its physicochemical and organoleptic properties. In this research, the optimization of oleogel production was done based on the hardness and oil migration rate, and the treatment containing 7.41 grams of carnauba wax and 4.41 grams of ethyl cellulose was selected as the optimal treatment. Then 5 types of mayonnaise samples were prepared and physicochemical and sensory tests were performed on them on days 1, 30 and 60. During the storage period, the amount of replaced oleogel had an inverse relationship with peroxide index, thiobarbituric acid and the amount of released oil and a direct relationship with the emulsion stability of the samples. Also, the results showed that the storage time has no significant effect on the color characteristics of the samples; But with increasing amount of oleogel, the *L component of the samples decreases, but the *a and *b components of the samples increase. In the organoleptic evaluation, at the end of the shelf life, all the treatments were in the optimal and moderate range.Therefore, the results showed that mayonnaise with desirable physicochemical and sensory properties can be prepared using oleogels based on sesame oil and organogels of ethylcellulose and carnoba wax.
                                                                                                                                    
 

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These days, investigation on using acoustofluidic microchannels in separation of microparticles and cells is under consideration. Working under optimum efficiency, these microchannels should be designed and manufactured truly. In this work, a new methodology for designing and manufacturing of acoustofluidic microchannels are explained. Then, a metallic microchannel with 2-nodes of pressure wave based on this method was developed. For mass production purpose, a low cost and reliable method which is CNC micromachining is used. Also, to conduct the heat generated by the wave, this microchannel was made out of aluminum and then polishing technique is applied. Then, the performance of this microchannel in agglomerating of human blood cells and BT-20 breast cancer cells to nodal lines was experimentally studied. The results showed that the applied design and manufacturing technique are suitable. Although some tests were performed to find temperature rise of microchannel due to damping effect, it was found that true design method and also using metals with high thermal conductivity can prevent the temperature increase to the point beyond which living cells will be hurt.

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Introduction: Retinoblastoma, the most prevalent pediatric eye cancer, arises from mutations in the RB1 gene, leading to the uncontrolled proliferation of retinal cells. This study introduces a heterotopic retinoblastoma model utilizing zebrafish, focusing on injecting the Y79 retinoblastoma cell line into the vitreous cavity for real-time tumor observation. Methods: By leveraging the transparent embryos and rapid eye development of zebrafish, we tracked the establishment and growth of fluorescently labeled tumors. Results: Results confirm tumor formation within three days, underscoring the model's relevance for in vivo studies. The zebrafish model capitalizes on the ease of maintenance, transparency for direct visualization, and genetic tractability, offering significant potential for high-throughput screening and therapeutic assessments. Conclusion: As the field progresses, this model promises to enhance our understanding of retinoblastoma biology and facilitate the discovery of effective treatments, addressing the critical need for innovative approaches in pediatric oncology