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Volume 11, Issue 3 (Summer 2023)
Abstract
Aims: This study aimed to develop fundamental motor skill activities based on game circuits that aim to improve the motor skills of children with dyspraxia.
Instrument & Methods: This research involved instrument development, initial revision, and field trials. Instruments in-game circuits were designed with various motor challenges specifically designed to facilitate the development of basic motor skills. In the initial trial phase, activities were implemented with the participation of several children with dyspraxia. Then, instruments and activities were adjusted based on feedback and findings from the initial trials. Field trials were conducted through the participation of larger groups of children with dyspraxia to evaluate the effectiveness and efficiency of the activities developed.
Findings: The development of fundamental motor skill activity based on the game circuit has a CVR value of 0.5, greater than the threshold limit of 0.62. Hence, it had good content validity in measuring the desired construct. The correlation calculation results showed a positive and significant relationship between the scores of assessors 1, 2, and 3 with a total score of assessors on aspects of movement skills, cognitive aspects, fun aspects, and attention focus. The ICC test results showed the instrument's reliability.
Conclusion: Developing fundamental motor skill activities through the game circuit approach can effectively improve the motor skills of children with dyspraxia.
Volume 26, Issue 5 (9-2024)
Abstract
MicroRNAs (miRNAs) are typically small, endogenous, non-coding RNAs molecules that regulate gene expression at post-transcriptional level by mRNA degradation or translational repression. They are composed of 18-26 nucleotides and are conserved during evolution for the development of new miRNAs in a variety of plants. Sugarcane (Saccharum officinarum) is generally a valuable food and forage crop grown all over the world. Until now, different sugarcane miRNAs have been characterized for plant development and stress responses. In this research, 50 unique conserved sugarcane miRNAs from 44 different miRNA families have been predicted using a variety of genomics-based tools. The predicted sugarcane miRNAs were validated using a set of 15 randomly chosen primers and RT-PCR. Stem loop secondary structures are created using MFOLD tool. The psRNA-Target algorithm identified 7,976 various protein targets of sof-miRNAs including 55 specific GO terms. They have significant targets in biological, cellular, and molecular functions. Moreover, the sof-miR5205a regulates sulfur compound biosynthetic process and 9653a directs ubiquitin-dependent protein catabolic process. Consequently, the RNA binding and thylakoid membrane are controlled by sof-miR9657b and 2091, respectively. As a result, the outcomes of the novel sugarcane miRNAs target a variety of substantial genes that aid in controlling the environment for sugarcane to produce a higher quality crop.
