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This research intends to identify and assess effect of personal factors and materiality of wrongdoing on whistle-blowing. Combination of qualitative and quantitative methods is applied and in qualitative method, Delphi technique used to identify each factor components in 4 stages applying Kenad’s coefficient which was 0/433. Then, in quantitative method, based on result of Delphi technique, a questionnaire was provided and its validity confirmed by CVI and CVR measures. Reliability confirmed by Cronbach’s alpha of 0/766. Therefore, questionnaire was distributed in target population and 274 were completed by medical staff and hospital administration in Alzahra Hospital of Isfahan. Gathered data was analyzed using Structural Equation Modeling. Results showed that goodness of fit and the model has reasonable adaption with experimental data. In appraising two factors of Personal and Materiality of Wrongdoing. Effect of Materiality of wrongdoing was accepted, but the effect of personal factors was not accepted.