Showing 6 results for بخشنده
Volume 4, Issue 3 (fall 2023)
Abstract
Background: Bicycle is one of the most important Types of non-motorized travel and one of the most important components of the clean urban transportation system. The paradigm shifts on and clean modes of travel have affected approaches to transportation and traffic engineering and also concepts of modern theories of this urbanism which is needs to scientific study. Furthermore, Despite the high position of the bicycle in the transportation aspects of cities, until now urban studies in the field of bicycles have been more practical, and theoretical approaches and theoretical insights have not been studied on the bicycle in a centralized and coherent way among the theories of urban development and urbanism.
Aims: The aim of this research is to read theoretically and qualitatively the position and dimensions of the bicycle in modern theories of urban planning as a form of range on new concepts and approaches, movements, intellectual movements; With the help of two angles, the general knowledge of the theories and the specific knowledge of the theories from the perspective of the position and place of the bicycle in the theories.
Methodology: The research approach of this study is qualitatively, based on documentary research and library studies and for Theoretical recognition of the position and dimensions of the bicycle in new theories of urbanism; it has used fourteen theories as a form of concepts, approach, movements, or intellectual movement in two formats of general reading and special readings.
Findings: The findings of the research indicate the perceptible cognitive capacities in the direction of positioning the bicycle directly or indirectly under the desired patterns of bicycle deployment in each of these fourteen theories. Furthermore, there are complementary polygonal tools supporting bicycle deployment and different dominant scientific views have been applied in each one.
Conclusion: Positioning the bicycle among a wide range of concepts, charters and modern intellectual movements of urbanism is possible and, in this way, some of the noticeable theoretical gaps in this field have been filled.
Volume 9, Issue 1 (Winter 2018)
Abstract
Aims: The induction of artificial over-expression of miRNAs is an appropriate approach to more effective cell differentiation. The significant role of microRNA-1(miR-1) has been reported in the development and differentiation of cardiac cells. Lentivirus is an effective vector for stable cell line production. The aim of this study was the production of recombinant HEK293T with miR-1 overexpression as a biological model for cardiac studies.
Materials & Methods: In this experimental study, HEK 293T cells were cultured in DMEM medium with 10% Fetal Bovine Serum (FBS) and L-glutamine 2mM and Penicillin-Streptomycin 1X in incubator medium. After cloning of miR-1 gene, recombinant clones were selected and the recombination was confirmed by sequencing. The miR-1 carrying vector and auxiliary vectors were packaged in the HEK293T to produce the recombinant virus. The infection of HEK293T by recombinant virus was performed in order to achieve stable cell line. Then, GFP fluorescent marker evaluated the efficiency of transfection and effective virus dilution. Finally, the alteration in expression level of miR-1 was assessed by qPCR. Data analysis was performed by comparing the threshold cycle and Pfaffl method.
Findings: The most GFP expression was detected in transfected cells by 150 micromole dilution. GFP fluorescent marker facilitated optimization and purification of recombinant cells. qPCR investigation demonstrated the significant increase in expression of miR-1 in transfected cells in comparison to controls.
Conclusion: The stable recombinant HEK293T miR-1 over-expressing cell line in lentivirus can be utilized as a suitable biological model for investigation of cardiac evolution and development processes.
Volume 10, Issue 4 (3-2021)
Abstract
Various factors play a role in the successful implementation of the business intelligence system. However, often, technological and instrumental factors of business intelligence have been considered by researchers, managers and investors. Therefore, in our research, we decided to use the business intelligence management approach to identify and rank the critical factors for the success of the implementation of business intelligence related to human resource factors, using the literature and opinions of experts. Therefore, for data collection, the Creswell’s thematic literature review was used, from which 121 sources were selected as the statistical population, 33 sources were selected using the exclusion criteria, and thus clusters and human factors influencing on the success of business intelligence was extracted and became the basis for a questionnaire based on pairwise comparisons. Utilizing the opinions of ten business intelligence to analyze the data, DEMATEL technique was used, which best shows the relationships of influence and effectiveness. The content validity of the questionnaire was confirmed by business intelligence experts and the reliability of the questionnaire was determined by Cronbach's alpha method. The results showed that among the four clusters, factors related to team members, factors related to the project manager, factors related to user acceptance and cooperation and factors related to the organization, respectively, factors related to the organization and factors related to the project manager are causal factors influencing on other factors.
Volume 13, Issue 56 (10-2015)
Abstract
This study aimed to evaluate the effect of squid protein hydrolysate prepared from protamex (P1, P2, P3) and alcalase (A1, A2, A3) enzymes respectively, at 0.5%, 1% and 1.5% concentration and also control sample (0%), on some physicochemical and organoleptic properties of low-fat set style yoghurt such as viscosity, synersis percentage, water holding capacity, acidity, pH, odor, taste, texture and color. Results showed that the lowest viscosity (416/66) was for control sample. Protein hydrolysates of both of enzymes increased viscosity while the highest amount was for P3 and A3. The highest pH and lowest acidity were for the control sample and protein hydrolysate in yogurt formulation decreased pH and increased acidity of samples. Maximum synersis obtained with control sample (4.47); protein hydrolysate decreased synersis while 1% protein hydrolysate with alcalase had the lowest synersis (0.33). Results of organoleptic tests showed that alcalase samples, especially in higher concentrations, modified odor and taste of low-fat yoghurt but these changes were not clear in texture and color. Generally, squid protein hydrolysate with alcalase and protamex in yoghurt formulation improved functional properties of low-fat yoghurt and it was more efficient in alcalase treatments in comparison with protamex.
Volume 15, Issue 81 (11-2018)
Abstract
Volume 20, Issue 2 (8-2017)
Abstract
Objective: Pathological changes to endothelial cells of the vessel wall may lead to vascular stenosis. In this study, we investigate damages that appear following radiotherapy in two states, single fraction and fractionation irradiation, as an effective sign of cytoskeletal and nuclei structure of vascular wall endothelial cells.
Methods: We irradiated human vein endothelial cells (HUVECs) with a Cobalt-60 therapy machine at radiation doses of 0, 2, 4, and 8 Gy. We stained the skeletal structure of the membrane and nuclei within 24 h after irradiation. This cell line received fractionation radiation therapy at doses from 0 to 8 Gy, in sub-fractions of 2 Gy, after which we stained the cytoskeleton. Morphological parameters such as area and perimeter of the cells and nuclei were determined, and we evaluated the cell shape index (CSI) for cells from each group.
Results: Increasing the irradiation dose from 0 to 8 Gy led to a significant decrease of CSI (approximately 56%) and a significant increase of nuclei shape index (approximately 85%; p<0.05). The cells’ areas and nuclei doubled (p<0.05). CSI parameter significantly decreased approximately 23% (4.5 times lower) during the radiotherapy fraction after application of the 8 Gy compared with control group cells.
Conclusion: After irradiation, we observed broken the membrane filaments that resulted in a new configuration, which led to increased cell and nuclei sizes along with alterations in the cell shape. Radiation therapy led to dose-dependent changes in morphological behavior response of the endothelial cells. Hence, it would be considered as a prognostic factor for behavior of healthy vascular cells in the process of radiotherapy.
