The roles of osteoprotegerin in bone diseases: a brief review | ||
| International Journal of Musculoskeletal Pain Prevention | ||
| Article 2, Volume 10, Issue 3, Autumn 2025, Pages 1246-1253 PDF (1.13 M) | ||
| Document Type: Systematic Review | ||
| DOI: 10.48311/ijmpp.2025.110577.0 | ||
| Authors | ||
| Masoumeh Mohammadi* ; Alireza Jalali | ||
| Sport Medicine and Knee Research Center, Milad Hospital, Tehran, Iran. | ||
| Abstract | ||
| Aim: This article aims to highlight the crucial role of Osteoprotegerin (OPG) in bone homeostasis and to propose it as a potential therapeutic target for common bone diseases. Method and Materials: A literature review was conducted focusing on the structure, function, and regulatory effects of OPG on osteoclast activity, as well as its mechanism as a decoy receptor that inhibits osteoclast formation. Findings: Evidence indicates that OPG plays a protective role against excessive bone loss by inhibiting osteoclast differentiation and activity. Its unique structure, consisting of a signal peptide and seven functional domains, enables it to act effectively in the extracellular space to maintain bone balance. Conclusion: OPG is a key regulator of bone metabolism and may represent a promising therapeutic target for the treatment and prevention of bone-related disorders. Increased attention to this protein could lead to innovative therapeutic strategies in metabolic bone disease management. | ||
| Keywords | ||
| Osteoprotegerin; Osteoporosis; Osteogenesis imperfecta; Paget's disease of bone; Bone metastasis; Osteomalacia; Rheumatoid arthritis | ||
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