The effect of 10 weeks interval training on lipocalin 2 gene expression in subcutaneous adipose tissue and lipid profile indices in obese Wistar rats | ||
| Pathobiology Reserach | ||
| Article 7, Volume 28, Issue 3, 2025, Pages 69-74 PDF (210.66 K) | ||
| Authors | ||
| Ali Mirzaei; Heshmatolah Parsian* | ||
| Department of Physical Education and Sport Science, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran | ||
| Abstract | ||
| Objective: The purpose of this study is to determine the effect of interval training on lipocalin-2 gene expression in subcutaneous adipose tissue, as well as the serum levels of lipid profile indices (TG, TC, LDL, HDL) in obesed Wistar rats. Methods: The statistical population consists of all male Wistar rats of the Pasteur Institute of Iran, from which 14 male rats (10-week-old) weighing (220±10 grams) were obesed by 8 weeks of high-fat diet and were randomly divided into interval (n=7) and control (n=7) groups. The exercise group participated in an interval training for 10 weeks, 5 sessions per week in the form of running on a treadmill. The control group did not participate in any exercise program. All rats were dissected 48 hours after the last training session. Finally, after measuring the variables and comparing them by independent t-test between groups. Results: Interval training resulted in significant decrease in lipocalin-2 expression (p = 0.029) and serum TC (p = 0.022). Serum HDL was also increased in response to interval training compared to control group (p = 0.024). TG (p = 0.398) and LDL (p = 0.658) remained no change by interval training. Conclusion: The improvement of the serum HDL and TC in response to interval training in obese rats is probably due to the decrease in lipocalin-2 gene expression in the subcutaneous adipose tissue. Knowing the main mechanisms responsible for these changes requires more studies in this field. | ||
| Keywords | ||
| : Obesity; Interval training; Lipocalin-2 gene expression; Lipid profile; Subcateneous adipose tissue | ||
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