Investigating the Effect of Hemoperfusion Therapy on Laboratory and Clinical Factors in COVID-19 Patients: A Cross-Sectional Study | ||
| Infection Epidemiology and Microbiology | ||
| Article 7, Volume 11, Issue 2, 2025, Pages 179-188 PDF (548.31 K) | ||
| Document Type: Original Research | ||
| DOI: 10.61186/iem.11.2.179 | ||
| Authors | ||
| Mousa Ghelighi-Ghojogh1; Amir Hossein Saberi2; saeid Amirkhanlou* 3 | ||
| 1Neonatal and Children’s Research Center, Department of Biostatistics and Epidemiology, School of Health, Faculty of Health, Golestan University of Medical Sciences, Gorgan, Iran | ||
| 2Medical Doctor, Golestan University of Medical Sciences, Gorgan, Iran | ||
| 3Department of Internal Medicine, Clinical Research Development Unit (CRDU), Shahid Sayad Shirazi Hospital, Golestan University of Medical Sciences, Gorgan, Iran | ||
| Abstract | ||
| Background: With the epidemic of the emerging COVID-19 disease in the world in 2019 and the lack of a definitive and effective treatment for it, medical science practically faced a new challenge, this study aimed to investigation the effect of hemoperfusion therapy on laboratory and clinical factors in COVID-19 patients. Materials & Methods: In this cross-sectional study, 49 patients with severe COVID-19, who had indications for hemoperfusion were examined in 2020-2021. The patients underwent four hemoperfusion sessions after inserting a vascular catheter and preparing a special filter. Changes in laboratory and clinical factors before and after each hemoperfusion session were carefully recorded, and the data were analyzed using SPSS software. Findings: The results of the study showed that the average age of the patients was 55.5 ± 13.9 years. Changes in the patients’ blood oxygen saturation levels after each hemoperfusion session showed a statistically significant improvement trend, the average values before and after the first session were 86.7±7.2% and 88.5±5.7%, respectively, indicating a significant increase (p= .009). Also, the inflammatory factor CRP (C-reactive protein) and blood platelet levels were significantly reduced after each hemoperfusion session. Conclusion: This study showed that hemoperfusion could improve patients’ blood oxygen saturation values without causing any special complications and could also have a clear effect on clearing inflammatory factors and CRP from the blood. | ||
| Keywords | ||
| Hemoperfusion; Covid-19; Clinical factors | ||
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