Infections and Their Impact on Multiple Sclerosis | ||
| Infection Epidemiology and Microbiology | ||
| Article 5, Volume 11, Issue 1, 2025, Pages 43-50 PDF (410.76 K) | ||
| Document Type: Original Research | ||
| DOI: 10.61186/iem.11.1.43 | ||
| Authors | ||
| Seyyed Amin Seyyed Rezaei1; Ata Moghimi2; Vahid Asgharzadeh3; Behroz Mahdavi Poor4; Mohammad Asgharzadeh5; Hossein Jalaei Nobari6; Mortaza Raeisi7; Ahmad Ali Khalili8; Jalil Rashedi* 9 | ||
| 1Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 2Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 3Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 4Infectious and Tropical Diseases Research Center, and Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 5Biotechnology Research Center, and Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 6Department of Islamic Studies, Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 7Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 8Department of Cardiovascular Surgery, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 9Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| Abstract | ||
| Aims: Multiple sclerosis (MS) is a prevalent central nervous system (CNS) disorder characterized by inflammation and demyelination of nerves. The incidence of this disease has markedly risen in diverse regions, including the Middle East. Any factor that alters the quality and quantity of immune system components or influences the migration of immune cells toward the CNS may contribute to MS development. Evidence suggests that paragenetic, genetic, and environmental factors may be involved in increasing MS risk. This study aimed to investigate the effect of various infections on MS incidence. Materials & Methods: This study included 475 MS patients and 260 healthy individuals from the Azeri population of East Azerbaijan province. Both groups filled out a questionnaire about their history of exposure to specific pathogens and infections before the age of 15.The relationship between a history of various infections and MS risk was examined.Findings: Mycoplasma pneumonia infection was significantly more prevalent in MS patients than in healthy individuals (p< .05). MS patients were more likely to suffer from common colds (p< .05), but no significant difference was observed regarding other infectious diseases (p> .05). Additionally, the prevalence of chronic infections was higher among MS patients (p< .05). Conclusion: M.pneumoniae infection, common colds, and chronic infections were significantly more common in MS patients than in healthy controls. However, no significant association was found between other infectious diseases and MS risk. These findings emphasize the possible role of specific pathogens in MS development, warranting further investigation into underlying mechanisms and contributing factors. | ||
| Keywords | ||
| Multiple sclerosis; Infections; Pneumonia; Common cold; Chronic | ||
| References | ||
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