Serum Level of Some Immunological Markers in COVID-19 Patients in Diyala Province, Iraq | ||
| Infection Epidemiology and Microbiology | ||
| Article 7, Volume 10, Issue 4, 2024, Pages 329-333 PDF (379.35 K) | ||
| Document Type: Original Research | ||
| DOI: 10.61186/iem.10.4.329 | ||
| Author | ||
| Shahrazad Ahmed Khalaf* | ||
| Department of biotechnology, College of Science, Diyala University, Diyala, Iraq | ||
| Abstract | ||
| Background: This study aimed to measure the levels of IL-1β, IL-18, and IFN-Ƴ in the sera of patients with severe COVID-19 in Diyala province in Iraq. Materials & Methods: Blood samples were collected from 60 patients in Baquba Teaching Hospital in Iraq between January and April 2021, these patients had clinical signs and symptoms of COVID-19, diagnosed by the hospital doctors; in addition, 30 samples were taken from healthy control people, and the levels of IL_1β, IL_18, and IFN_Ƴ markers were detected in COVID-19 patients and the control group by ELISA (enzyme-linked immunosorbent assay) technique. Findings: This study displayed the high level of IL_1β, IL_18, and IFN_Ƴ in COVID-19 patients compared with the control group (154.04 ± 16.54 versus 85.41 ± 8.9 pg/mL, 82.88 ± 7.96 versus 66.67 ± 9.34 pg/mL, and 116.06 ± 26.5 versus 97.96 ± 12.2pg/mL, respectively). This study also showed a high prevalence of COVID-19 in males compared to females. In the sera of COVID-19 patients, the levels of IL_1β, IL_18, and IFN_Ƴ were noticeably higher in females than in males. Conclusion: There was a significant difference in the levels of IL_1β, IL_18, and IFN-Ƴ between the study groups; also, they were higher in females than in males. | ||
| Keywords | ||
| COVID-19 patient; IL_1β; IL_18; IFN_Ƴ | ||
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