Funmilayo, Akinseye Janet, Agboola, Oluwaseun, Agboola, Samuel, Oluboyo, Bernard, Egbebi, Adebimpe, Sijuade, Abayomi, Ayinla, Zainab, Adegbuyi, Adekunle, Agu, Chidera, Aikhomu, Victoria, Ogunfolakan, Ogunbola, Onyejiaka, Juliet, Oludare, Tunrayo, Agboola, Adeorite (2024). The Roles of Genomics and Proteomics in Human Parasitology: Closing the Knowledge Gap. , 10(2), 157-174. doi: 10.52547/iem.10.2.157
Akinseye Janet Funmilayo; Oluwaseun Agboola; Samuel Agboola; Bernard Oluboyo; Adebimpe Egbebi; Abayomi Sijuade; Zainab Ayinla; Adekunle Adegbuyi; Chidera Agu; Victoria Aikhomu; Ogunbola Ogunfolakan; Juliet Onyejiaka; Tunrayo Oludare; Adeorite Agboola. "The Roles of Genomics and Proteomics in Human Parasitology: Closing the Knowledge Gap". , 10, 2, 2024, 157-174. doi: 10.52547/iem.10.2.157
Funmilayo, Akinseye Janet, Agboola, Oluwaseun, Agboola, Samuel, Oluboyo, Bernard, Egbebi, Adebimpe, Sijuade, Abayomi, Ayinla, Zainab, Adegbuyi, Adekunle, Agu, Chidera, Aikhomu, Victoria, Ogunfolakan, Ogunbola, Onyejiaka, Juliet, Oludare, Tunrayo, Agboola, Adeorite (2024). 'The Roles of Genomics and Proteomics in Human Parasitology: Closing the Knowledge Gap', , 10(2), pp. 157-174. doi: 10.52547/iem.10.2.157
Funmilayo, Akinseye Janet, Agboola, Oluwaseun, Agboola, Samuel, Oluboyo, Bernard, Egbebi, Adebimpe, Sijuade, Abayomi, Ayinla, Zainab, Adegbuyi, Adekunle, Agu, Chidera, Aikhomu, Victoria, Ogunfolakan, Ogunbola, Onyejiaka, Juliet, Oludare, Tunrayo, Agboola, Adeorite The Roles of Genomics and Proteomics in Human Parasitology: Closing the Knowledge Gap. , 2024; 10(2): 157-174. doi: 10.52547/iem.10.2.157

The Roles of Genomics and Proteomics in Human Parasitology: Closing the Knowledge Gap

Infection Epidemiology and Microbiology
Article 8, Volume 10, Issue 2, 2024, Pages 157-174    PDF (743.24 K)
Document Type: Systematic Review
DOI: 10.52547/iem.10.2.157
Authors
Akinseye Janet Funmilayo* 1; Oluwaseun Agboola2; Samuel Agboola3; Bernard Oluboyo1; Adebimpe Egbebi4; Abayomi Sijuade5; Zainab Ayinla6; Adekunle Adegbuyi7; Chidera Agu1; Victoria Aikhomu1; Ogunbola Ogunfolakan1; Juliet Onyejiaka1; Tunrayo Oludare8; Adeorite Agboola9
1Medical Laboratory Science Department, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Nigeria.
2Institute for Drug Research and Development, Bogoro Research Centre, Afe Babalola University, Ado-Ekiti, Nigeria.
3Department of Pharmacology and Toxicology, College of Pharmacy, Afe Babalola University, Ado-Ekiti, Nigeria.
4Medical Laboratory Science Department, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Nigeria, Ado-Ekiti.
5Department of Pharmacology and Therapeutic, College of Medicine, Ekiti State University, Ekiti State, Nigeria.
6Department of Biochemistry and Molecular Biology, Obafemi Awolowo University, Ile-Ife, Nigeria.
7Department of Pharmacology and Toxicology, Faculty of Pharmacy, Federal University Oye-Ekiti, Nigeria.
8Department of Community Medicine, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti.
9Integrated Medical Sciences Department, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Nigeria.
Abstract
Background: The complicated host-parasite relationships have hindered the effective diagnosis, treatment, and control of human parasitic diseases. This review examines how genomics and proteomics are unraveling these complex interactions and transforming human parasitology.

Materials & Methods: Related studies were chosen according to the PRISMA flow diagram. An extensive literature search between January 1, 2022 and March 31, 2023 was conducted in PubMed, Scopus, and Web of Science databases, and a systematic screening process was undertaken, resulting in the identification and inclusion of 72 studies in this narrative review on the applications of genomics and proteomics in human parasitology research. Articles that were duplicates, irrelevant based on title/abstract screening, unavailable, or irrelevant based on full text review were excluded from the study.

Findings: A total of 453 records were retrieved, of which 72 articles remained after title, abstract, and full text screening. Genomics and proteomics have elucidated parasite biology, enabled precision diagnostics, and guided drug development by providing molecular insights into host-parasite interactions. However, challenges remain, including computational complexity and translation of findings to human infections.

Conclusion: The integration of genomics and proteomics has allowed an unprecedented understanding of human parasites and holds great promise for improving diagnosis, treatment, and control.
Keywords
Parasitology; Genomics; Proteomics; Biomarkers; Drug discovery
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