Chandra Sekar, Praveen Kumar, Veerabathiran, Ramakrishnan (2024). A comprehensive investigation of the association between IL-6 rs1800795 (-147G/C) and severity of COVID-19: A meta-analysis of case-control studies. , 10(2), 141-152. doi: 10.52547/iem.10.2.141
Praveen Kumar Chandra Sekar; Ramakrishnan Veerabathiran. "A comprehensive investigation of the association between IL-6 rs1800795 (-147G/C) and severity of COVID-19: A meta-analysis of case-control studies". , 10, 2, 2024, 141-152. doi: 10.52547/iem.10.2.141
Chandra Sekar, Praveen Kumar, Veerabathiran, Ramakrishnan (2024). 'A comprehensive investigation of the association between IL-6 rs1800795 (-147G/C) and severity of COVID-19: A meta-analysis of case-control studies', , 10(2), pp. 141-152. doi: 10.52547/iem.10.2.141
Chandra Sekar, Praveen Kumar, Veerabathiran, Ramakrishnan A comprehensive investigation of the association between IL-6 rs1800795 (-147G/C) and severity of COVID-19: A meta-analysis of case-control studies. , 2024; 10(2): 141-152. doi: 10.52547/iem.10.2.141

A comprehensive investigation of the association between IL-6 rs1800795 (-147G/C) and severity of COVID-19: A meta-analysis of case-control studies

Infection Epidemiology and Microbiology
Article 6, Volume 10, Issue 2, 2024, Pages 141-152    PDF (1.08 M)
Document Type: Analytic Review
DOI: 10.52547/iem.10.2.141
Authors
Praveen Kumar Chandra Sekar; Ramakrishnan Veerabathiran*
Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu 603103, India
Abstract
Background: To evaluate the relationship between COVID-19 and IL-6 polymorphism, a meta- analysis was conducted on seven studies, comprising 2265 controls and 1686 cases.

Materials & Methods: The literature on IL-6 polymorphism and its correlation with COVID-19 severity was extensively reviewed, covering research up to August 2023. Various databases including Google Scholar, PubMed, and Embase were utilized for literature search. Data analysis was performed using Cochrane Rob Tool 2 and Review Manager 5 software.

Findings: In this meta-analysis, none of the models showed a correlation between IL-6 polymorphism and COVID-19, including the allelic (G vs C, OR: 1.01, 95% CI: 0.63–1.64, p= .22, I2=91%), homozygote (GG vs. CC, OR: 1.08, 95% CI: 0.41–2.83, p= .87, I2=79%),

heterozygote (GC vs. CC, OR: 0.78, 95% CI: 0.34–1.78, p= .55, I2=73%), dominant (GG + GC vs CC, OR: 0.79, 95% CI: 0.32–1.95, p= .61, I2=81%), and recessive (OR: 1.26, 95% CI:

0.51–3.10, p= .61, I2=81%) models. Notably, funnel plot analysis revealed no indication of publication bias.

Conclusion: The findings of this meta-analysis indicated no significant correlation between IL-6 polymorphism and COVID-19 severity, suggesting insufficient data to establish a link between IL-6 (rs1800795) and more severe COVID-19 cases.
Keywords
Interleukin-6; Severity; Covid-19; Gene polymorphism
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