Madani, Fatemeh, Kazemzadeh, Yaser, Mirzaiyan Shanjani, Sanaz, Shirvani, Hossein (2025). The effect of a selected combination training on the PGC-1α and mTORc1 expression in the quadriceps muscle of aged male rats. , 28(3), -.
Fatemeh Madani; Yaser Kazemzadeh; Sanaz Mirzaiyan Shanjani; Hossein Shirvani. "The effect of a selected combination training on the PGC-1α and mTORc1 expression in the quadriceps muscle of aged male rats". , 28, 3, 2025, -.
Madani, Fatemeh, Kazemzadeh, Yaser, Mirzaiyan Shanjani, Sanaz, Shirvani, Hossein (2025). 'The effect of a selected combination training on the PGC-1α and mTORc1 expression in the quadriceps muscle of aged male rats', , 28(3), pp. -.
Madani, Fatemeh, Kazemzadeh, Yaser, Mirzaiyan Shanjani, Sanaz, Shirvani, Hossein The effect of a selected combination training on the PGC-1α and mTORc1 expression in the quadriceps muscle of aged male rats. , 2025; 28(3): -.

The effect of a selected combination training on the PGC-1α and mTORc1 expression in the quadriceps muscle of aged male rats

Pathobiology Reserach
Article 3, Volume 28, Issue 3, 2025    PDF (728.85 K)
Document Type: Original Research
Authors
Fatemeh Madani1; Yaser Kazemzadeh* 1; Sanaz Mirzaiyan Shanjani1; Hossein Shirvani2
1Dept.of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Islamic Azad University, Islamshahr Branch, Islamshahr, Iran
2Dept.Exercise Physiology Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences,Tehran, Iran
Abstract
Introduction: Many hormonal and genetic factors are involved in sarcopenia in old age. In the present study, the effect of combined (aerobic and resistance) training was measured on the expression of PGC-1α and mTORc1 genes in the quadriceps muscle of aged rats.

Methods: 16 aged male Wistar rats (22 months old) were randomly assigned to exercise (n=8) and control (n=8) groups. The rats in the exercise group performed 8 weeks of combined (resistance and aerobic) training, and the control group did not participate in the training program. Expression of PGC-1α and mTORc1 genes in quadriceps muscle was measured 48 hours after the last training session. Data were compared between the 2 groups by independent t-test at a significance level of alpha less than 0.5 percent (SPSS 22.0).

Results: Based on analysis data, combined training resulted in significant increase in PGC-1α and mTORc1 genes expression in quadriceps muscle compared with control rats (P=0.001).

Conclusion: Based on the available evidence, combined training may slow down the rate of sarcopenia in old age by increasing PGC-1α /mTORc1 pathway expression. Further studies are needed to understand the underlying mechanisms of this process.
Keywords
Combined Training; Sarcopenia; Aged rats; Genes expression; Quadriceps muscle
References
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