hosseini bahman, Marzieh, arshadi, Sajad, Shahedi, Valiollah, Banaeifar, Abdol Ali (2025). The impact of aerobic training on insulin resistance with emphasis on changes in adropin and fetuin-A in sedentary overweight females. , 28(2), 63-71.
Marzieh hosseini bahman; Sajad arshadi; Valiollah Shahedi; Abdol Ali Banaeifar. "The impact of aerobic training on insulin resistance with emphasis on changes in adropin and fetuin-A in sedentary overweight females". , 28, 2, 2025, 63-71.
hosseini bahman, Marzieh, arshadi, Sajad, Shahedi, Valiollah, Banaeifar, Abdol Ali (2025). 'The impact of aerobic training on insulin resistance with emphasis on changes in adropin and fetuin-A in sedentary overweight females', , 28(2), pp. 63-71.
hosseini bahman, Marzieh, arshadi, Sajad, Shahedi, Valiollah, Banaeifar, Abdol Ali The impact of aerobic training on insulin resistance with emphasis on changes in adropin and fetuin-A in sedentary overweight females. , 2025; 28(2): 63-71.

The impact of aerobic training on insulin resistance with emphasis on changes in adropin and fetuin-A in sedentary overweight females

Pathobiology Reserach
Article 6, Volume 28, Issue 2, 2025, Pages 63-71    PDF (322.3 K)
Document Type: Original Research
Authors
Marzieh hosseini bahman1; Sajad arshadi* 1; Valiollah Shahedi2; Abdol Ali Banaeifar3
1Department of exercise physiology, South tehran Branch, Islamic Azad University, Tehran, Iran
2Department of Physical Education and Sports Sciences, Parand Branch, Islamic Azad University, Tehran, Iran
3Department of Physical Education and Sports Sciences, South Tehran Branch, Islamic Azad University, Tehran, Iran
Abstract
Introduction: Disruption of inflammatory profile in the presence of obesity and overweight is associated with reduced insulin action in target cells. In the present study, the effect of aerobic training on insulin resistance is evaluated with an emphasis on possible changes in adropin and fetuin-A in overweight women.

Methods: For this purpose, 24 overweight adult females (26 ≤ BMI ≤ 30) were randomly assigned into experimental (n=12) or control (n=12) groups. The experimental group underwent an 8-week aerobic training of 3 sessions weekly, and the control group did not participate in the training. 24 hours before and 48 hours after exercise training, fasting blood sample was taken to measure serum levels of adropin, fetuin-A and insulin resistance in the 2 groups. Data were compared between the two groups by independent and paired sample t test at a significance level of less than 0.5 percent.

Results: No significant difference was observed in all variables between groups at baseline (p < 0.05). Aerobic training resulted in significant increase in serum adropin (p = 0.001) and decrease in Fetuin-A (p = 0.001) and insulin resistance (p = 0.019) in experimental groups. All variables remained without change in control group (p < 0.05)

Conclusion: The improvement in insulin resistance following aerobic training may be attributed to a decrease in fetuin-A and an increase in adropin in response to this type of exercise. However, further studies are needed to understand the underlying mechanisms responsible for these changes.
Keywords
Aerobic training; Overweight; Adropin; Fetuin-A; Insulin resistance
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