Ghanei, Rayhaneh, Banaeifar, Abdol Ali, Gorzi, Ali, Arshadi, Sajad (2024). The effect of testosterone consumption during resistance training on the expression of some genes related to heart damage of male Wistar rats. , 27(4), 45-52.
Rayhaneh Ghanei; Abdol Ali Banaeifar; Ali Gorzi; Sajad Arshadi. "The effect of testosterone consumption during resistance training on the expression of some genes related to heart damage of male Wistar rats". , 27, 4, 2024, 45-52.
Ghanei, Rayhaneh, Banaeifar, Abdol Ali, Gorzi, Ali, Arshadi, Sajad (2024). 'The effect of testosterone consumption during resistance training on the expression of some genes related to heart damage of male Wistar rats', , 27(4), pp. 45-52.
Ghanei, Rayhaneh, Banaeifar, Abdol Ali, Gorzi, Ali, Arshadi, Sajad The effect of testosterone consumption during resistance training on the expression of some genes related to heart damage of male Wistar rats. , 2024; 27(4): 45-52.

The effect of testosterone consumption during resistance training on the expression of some genes related to heart damage of male Wistar rats

Pathobiology Reserach
Article 6, Volume 27, Issue 4, 2024, Pages 45-52    PDF (666.86 K)
Document Type: Original Research
Authors
Rayhaneh Ghanei* 1; Abdol Ali Banaeifar2; Ali Gorzi3; Sajad Arshadi1
1Department of Physical Education and Sports Sciences, South Tehran Branch, Islamic Azad University, Tehran, Iran
2Department of Physical Education and Sports Sciences, Islamic Azad University, South Tehran branch, Tehran, Iran
3Department of Sport Sciences, University of Zanjan, Zanjan, Iran
Abstract
Introduction: Many studies have addressed the side effects of anabolic steroid abuse in different tissues such as heart tissue. The purpose of this research is to study the effect of 8 weeks of resistance training and testosterone consumption on some indicators of heart tissue damage in male rats.

Methods: 21 adult male Wistar rats aged 8 weeks (220 ± 10 g) were randomly divided into 3 groups: control, training (resistance training) and training + testosterone groups. The intervention of resistance exercise and testosterone injection lasted for 8 weeks. Resistance exercises were performed 5 times a week in the form of climbing a step ladder with resistance applied by tying a weight to the tail (4 sets, 6 repetitions in each set). Testosterone enanthate was injected intramuscularly 3 days a week (20 mg/kg). One-way ANOVA and Tukey's post hoc test were used to compare variables.

Results: Creatine kinase-MB (CK-MB) expression increased significantly in the training + testosterone compared to the control group (P<0.05). No significant difference was observed in troponin expression between the studied groups (P>0.05).

Conclusion: It seems that testosterone enanthate administration during resistance training leads to cardiac tissue damage in laboratory rats.
Keywords
resistance training; CKMB; troponin; Heart tissue; Testosterone enanthate
References
Statistics
Article View: 100
PDF Download: 37
Statistics
Number of Journals45
Number of Issues2,171
Number of Articles24,674
Article View24,431,663
PDF Download17,550,033