Assessing the Relationship Between D-dimer and IL-6 Levels and Clinical Outcomes in Elderly COVID-19 Patients | ||
| Infection Epidemiology and Microbiology | ||
| Article 8, Volume 10, Issue 1, 2024, Pages 71-77 PDF (681.6 K) | ||
| Document Type: Original Research | ||
| DOI: 10.61186/iem.10.1.71 | ||
| Authors | ||
| Christopher Paul Clement Jenil Dhas1; Yoganathan Chidambaram* 2; Srinivasan Kesavan1; Kalaivanee Balasubramaniam3; Sujith Kumar Sivaraj4; Saravanan Thangavelu4 | ||
| 1Assistant Professor, Department of General Medicine, PSG Institute of Medical Sciences and Research, Coimbatore, India. | ||
| 2Associate Professor, Department of General Medicine, PSG Institute of Medical Sciences and Research, Coimbatore, India | ||
| 3Senior Resident, Department of General Medicine, PSG Institute of Medical Sciences and Research, Coimbatore, India. | ||
| 4Professor, Department of General Medicine, PSG Institute of Medical Sciences and Research, Coimbatore, India. | ||
| Abstract | ||
| Background: This study aimed to evaluate serum levels of interleukin-6 (IL-6) and D-dimer and their association with morbidity and mortality in elderly coronavirus disease-19 (COVID-19) patients and to assess their clinical outcomes. Materials & Methods: This retrospective observational study was conducted on elderly COVID-19 patients (≥60 years) diagnosed via reverse transcription-polymerase chain reaction (RT-PCR) or radiological tests in a South Indian tertiary care hospital. Data encompassed demographics, comorbidities, symptoms, IL-6 and D-dimer levels, oxygen (O2) requirement, duration of hospital stay, and outcomes. Statistical analysis involved Chi-square test. A p-value of < .05 was considered statistically significant. Findings: Among 1448 screened patients, 1380 patients with a mean age of 68.85±6.985 years were included in this study, of whom 61.67% were male. The mortality rate was 12.1% in males and 11% in females. Fever, cough, hypertension, and diabetes were common in most of the patients. The mean D-dimer and IL-6 levels were 2.687±5.189 mg/L fibrinogen equivalent units (FEU) and 95.72±335.62 pg/mL, respectively. Elevated D-dimer (71%) and IL-6 (87.7%) levels were significantly associated with oxygen requirement, morbidity, and mortality (p= .000). Sub-group analysis revealed a significant association between D-dimer and IL-6 levels and O2 requirement and mortality in diabetic and hypertensive patients (p= .000). Conclusion: Serum IL-6 and D-dimer levels are significantly associated with morbidity and mortality in elderly COVID-19 patients. Elevated levels of these biomarkers also influence O2 requirement and mortality in patients with comorbidities, suggesting their potential use in risk stratification and management strategies for this vulnerable population. | ||
| Keywords | ||
| Covid-19; D-dimer; geriatric; Interleukin-6; mortality | ||
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