Rezvani, Mohammad Ebrahim, Izadi, Mahin (2023). Chamomile Infusion Reduces Ovarian Weight and Abdominal Vascular Permeability in a Rat Model of Ovarian Hyperstimulation Syndrome. , 26(1), 25-28.
Mohammad Ebrahim Rezvani; Mahin Izadi. "Chamomile Infusion Reduces Ovarian Weight and Abdominal Vascular Permeability in a Rat Model of Ovarian Hyperstimulation Syndrome". , 26, 1, 2023, 25-28.
Rezvani, Mohammad Ebrahim, Izadi, Mahin (2023). 'Chamomile Infusion Reduces Ovarian Weight and Abdominal Vascular Permeability in a Rat Model of Ovarian Hyperstimulation Syndrome', , 26(1), pp. 25-28.
Rezvani, Mohammad Ebrahim, Izadi, Mahin Chamomile Infusion Reduces Ovarian Weight and Abdominal Vascular Permeability in a Rat Model of Ovarian Hyperstimulation Syndrome. , 2023; 26(1): 25-28.

Chamomile Infusion Reduces Ovarian Weight and Abdominal Vascular Permeability in a Rat Model of Ovarian Hyperstimulation Syndrome

Pathobiology Reserach
Article 4, Volume 26, Issue 1, 2023, Pages 25-28    PDF (365.3 K)
Document Type: Original Research
Authors
Mohammad Ebrahim Rezvani* 1; Mahin Izadi2
1Yazd Neuroendocrine Research Center, School of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran
2Department of Reproductive Biology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract
Introduction: The process by which new blood vessels are formed from pre-existing vessels is called angiogenesis. Regarding chamomile (Matricaria chamomilla, MC) contains anti-angiogenesis properties, Herein; the effect of MC infusion on ovarian hyperstimulation syndrome (OHSS) was evaluated using an experimental model of OHSS.

Methods: The sample (10 g) of the shade dried plant material was added to 1000 mL of boiling distilled water. This infusion kept for 10 min, then filtered and dried. OHSS was induced through the intra-peritoneal injection of pregnant mare serum gonadotropin (PMSG) and hCG. Treated groups were administered with 25 mg/kg of MC extract. Body and ovary weights were measured. Vascular permeability (VP) was determined through the injection of 2 mL of 5 mM Evans Blue and staining was quantified at 600 nm using a spectrophotometry.

Result: body weight gain observed in control OHSS group were attenuated by MC extract application (P<0.05). Also, MC decreased the ovarian weight and diameter in OHSS group. Vascular permeability was significantly decreased in MC treated rat in compared to control OHSS rats (P<0.05).

Conclusion: the results of the present study in a rat model indicate that MC infusion can reduce the severity of OHSS complications by reducing vascular permeability and protein leakage.
Keywords
ovarian hyperstimulation syndrome; Chamomile; vascular permeability
References
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