Karimi, Omolbanin, Hassanshahi, Jalal, Shamsizadeh, Ali (2022). The Role of Medicinal Plants in Treating Mild Cognitive Impairment: A Focus on Mitophagy Modulation. , 25(4), 43-49.
Omolbanin Karimi; Jalal Hassanshahi; Ali Shamsizadeh. "The Role of Medicinal Plants in Treating Mild Cognitive Impairment: A Focus on Mitophagy Modulation". , 25, 4, 2022, 43-49.
Karimi, Omolbanin, Hassanshahi, Jalal, Shamsizadeh, Ali (2022). 'The Role of Medicinal Plants in Treating Mild Cognitive Impairment: A Focus on Mitophagy Modulation', , 25(4), pp. 43-49.
Karimi, Omolbanin, Hassanshahi, Jalal, Shamsizadeh, Ali The Role of Medicinal Plants in Treating Mild Cognitive Impairment: A Focus on Mitophagy Modulation. , 2022; 25(4): 43-49.

The Role of Medicinal Plants in Treating Mild Cognitive Impairment: A Focus on Mitophagy Modulation

Pathobiology Reserach
Article 6, Volume 25, Issue 4, 2022, Pages 43-49    PDF (1.59 M)
Document Type: Systematic Review
Authors
Omolbanin Karimi1; Jalal Hassanshahi2; Ali Shamsizadeh* 3
1Physiology-Pharmacology Research Center, Research Institute on Basic Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
2Department of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
3Occupational safety and health research center, NICICO, WSO and Rafsanjan University of Medical Sciences, Rafsanjan, Iran
Abstract
Mild cognitive impairment (MCI) is a transitional stage between normal aging and dementia, characterized by cognitive decline that is more pronounced than expected for age. While the exact mechanisms underlying MCI remain elusive, mounting evidence suggests that impaired mitophagy, a cellular process responsible for removing damaged mitochondria, may contribute to its development. Medicinal plants, rich in bioactive compounds, have shown promise in treating MCI. This review explores the potential of medicinal plants to ameliorate MCI by modulating mitophagy. We delve into the intricate interplay between mitophagy dysfunction and MCI, highlighting the pathways involved. Furthermore, we examine the reported effects of various medicinal plants on mitophagy, emphasizing their potential to restore mitochondrial homeostasis and protect cognitive function. Finally, we discuss future research directions and perspectives on the therapeutic potential of medicinal plants in MCI management.
Keywords
Mild cognitive impairment; mitophagy; Medicinal plants
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