Fakhredini, Kamal, Soleimanjahi, Hooreih, Banijamali, Razieh Sadat, Bamdad, Taravat (2021). Evaluation of Mutation Spread in The SARS-CoV2 Genome. , 23(0), 41-49.
Kamal Fakhredini; Hooreih Soleimanjahi; Razieh Sadat Banijamali; Taravat Bamdad. "Evaluation of Mutation Spread in The SARS-CoV2 Genome". , 23, 0, 2021, 41-49.
Fakhredini, Kamal, Soleimanjahi, Hooreih, Banijamali, Razieh Sadat, Bamdad, Taravat (2021). 'Evaluation of Mutation Spread in The SARS-CoV2 Genome', , 23(0), pp. 41-49.
Fakhredini, Kamal, Soleimanjahi, Hooreih, Banijamali, Razieh Sadat, Bamdad, Taravat Evaluation of Mutation Spread in The SARS-CoV2 Genome. , 2021; 23(0): 41-49.

Evaluation of Mutation Spread in The SARS-CoV2 Genome

Pathobiology Reserach
Article 3, Volume 23, Issue 0, 2021, Pages 41-49    PDF (1.14 M)
Document Type: Analytic Review
Authors
Kamal Fakhredini1; Hooreih Soleimanjahi* 2; Razieh Sadat Banijamali1; Taravat Bamdad1
1Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
2Postal Code: 1411713116, Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Abstract
The Coronaviridae family includes viruses that are considered the causative agents of respiratory infections, and among human RNA viruses have the largest genome. Coronaviruses undergo elusive genetic changes through mutation during replication. A gene mutation is a permanent alteration in the nucleic acid sequence; if it occurs in large numbers, it causes changes in the biological features of a species. Fundamentally, viruses adapt to the human body during replication. Several studies have shown that most mutations do not have much effect on pathogenicity. Sequence diversity in new coronaviruses is very low. However, antigen drift has been observed among some coronaviruses. Most coronavirus mutations occur intermittently in Iran and other countries and have little effect on the pathogenicity of the virus but have increased its rate of transmission. In mutated viruses, deletion of nucleotide sequences has been observed relatively in some reading frames extensively. Studies have shown that the host protein induced mutagenesis through interaction via viral proteins. The most important mutation in SARS-CoV2 compared to the original Wuhan virus was the spike D614G mutation and the lineage of B.1.1.7, 20I/501Y.V1become the dominant and exhibit greater virus spread but did not associate with higher viral loads and morbidity. However, it may affect the effectiveness of the vaccines and mortality rate.
Keywords
SARS-CoV2; Covid-19; Mutation; Coronavirus
References
Statistics
Article View: 114
PDF Download: 60
Statistics
Number of Journals45
Number of Issues2,171
Number of Articles24,674
Article View24,431,435
PDF Download17,549,934