Safarzadeh Kozani, Pooria, rahbarizadeh, fatemeh, Safarzadeh Kozani, صفرزاده کوزانی, Sadeghi, Zeinab, Darzi Eslam, Elham (2021). A review on SARS-CoV-2: virology aspects, therapy and vaccine development. , 23(0), 1-29.
Pooria Safarzadeh Kozani; fatemeh rahbarizadeh; صفرزاده کوزانی Safarzadeh Kozani; Zeinab Sadeghi; Elham Darzi Eslam. "A review on SARS-CoV-2: virology aspects, therapy and vaccine development". , 23, 0, 2021, 1-29.
Safarzadeh Kozani, Pooria, rahbarizadeh, fatemeh, Safarzadeh Kozani, صفرزاده کوزانی, Sadeghi, Zeinab, Darzi Eslam, Elham (2021). 'A review on SARS-CoV-2: virology aspects, therapy and vaccine development', , 23(0), pp. 1-29.
Safarzadeh Kozani, Pooria, rahbarizadeh, fatemeh, Safarzadeh Kozani, صفرزاده کوزانی, Sadeghi, Zeinab, Darzi Eslam, Elham A review on SARS-CoV-2: virology aspects, therapy and vaccine development. , 2021; 23(0): 1-29.

A review on SARS-CoV-2: virology aspects, therapy and vaccine development

Pathobiology Reserach
Article 1, Volume 23, Issue 0, 2021, Pages 1-29    PDF (1.16 M)
Document Type: Analytic Review
Authors
Pooria Safarzadeh Kozani1; fatemeh rahbarizadeh* 2; صفرزاده کوزانی Safarzadeh Kozani3; Zeinab Sadeghi1; Elham Darzi Eslam1
1Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
2Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IranResearch and Development Center for Biotechnology (RDCB), Tarbiat Modares University, Tehran, Iran
3Department of Medical Biotechnology, Faculty of Paramedicine, Guilan University of Medical Sciences, Rasht, Iran
Abstract
Coronavirus disease 2019 (COVID-19) is a virally-induced pneumonia caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). This is the third disease-causing coronavirus after severe acute respiratory syndrome coronavirus (SARS-CoV) and the middle east respiratory syndrome coronavirus (MERS-CoV) which has been known in the human population in the 21st century. To this date (20th of Mehr, 1399), more than thirty-four million people have been infected by this virus and more than a million have lost their lives because of it which further signifies the importance of COVID-19 prevention and treatment. In this review article, we first take a look at the history of the famous coronaviruses and then introduce the genetic and pathophysiology of SARS-CoV-2 in a detailed manner. After discussing the related clinical manifestations, we shed a light on the treatments that have been assessed to this date. In the end, we will briefly discuss the vaccines that are currency being developed and highlight their success rate, so far. It is delightful to assert that out own research team is currently developing an oral and/or respiratory vaccine against SARS-CoV-2 which is composed of spike-surface decorated chitosan nanoparticles.
Keywords
COVID19; SARS-CoV-2; Vaccines; antiviral drugs; Monoclonal antibodies; clinical manifestation; serum therapy; cytokine storm
References
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