Rezaei, Mahtab, Rajabbeigi, Elham (2020). Effect of hydroalcoholic extract of Lavender on apoptosis of liver cancer cells (HepG2). , 23(4), -.
Mahtab Rezaei; Elham Rajabbeigi. "Effect of hydroalcoholic extract of Lavender on apoptosis of liver cancer cells (HepG2)". , 23, 4, 2020, -.
Rezaei, Mahtab, Rajabbeigi, Elham (2020). 'Effect of hydroalcoholic extract of Lavender on apoptosis of liver cancer cells (HepG2)', , 23(4), pp. -.
Rezaei, Mahtab, Rajabbeigi, Elham Effect of hydroalcoholic extract of Lavender on apoptosis of liver cancer cells (HepG2). , 2020; 23(4): -.

Effect of hydroalcoholic extract of Lavender on apoptosis of liver cancer cells (HepG2)

Pathobiology Reserach
Article 1, Volume 23, Issue 4, 2020    PDF (650.53 K)
Document Type: Original Research
Authors
Mahtab Rezaei1; Elham Rajabbeigi* 2
1Department of Biochemistry-Biophysics, Faculty of Advance Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
22. Department of Developmental Biology, Faculty of Advance Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Abstract
Objective: Despite many advances in cancer treatment and control, significant deficiencies remain and the rate of cancer growth is increasing. Due to the side effects of using chemicals and radiation, the use of herbs can have fewer side effects for the patient. The aim of this study was to investigate the potential anticancer effects of alcoholic extract of Lavender on inhibition and growth of HepG2 cell lines.

Materials and Methods: In this study, the effect of alcoholic extract of lavender (10,100,1000 and 1 μg / ml) on HepG2 liver cancer cell line was studied. MTT assay was used to evaluate the toxicity of lavender extract and cell viability. Cell cycle changes were assessed using a flow cytometer.

Oxygen-free species production and membrane lipid peroxidation were also measured.

Results: Results showed that alcoholic extract of Lavender has anti-cancer effect on HepG2 cell line. After confirming the effect of lavender extract on cell cycle, the results obtained from the evaluation of membrane lipid peroxidation and production of free reactive species were also significant.
Conclusion: According to the results of this study, the alcoholic extract of Lavender was reported as a potential anticancer agent and is one of the therapeutic strategies in liver cancer.
Keywords
Apoptosis; Cell cycle; Hepatic cancer (HepG2); Lavender
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