Influence of Strontium Substitution on Osteogenesis of Bioglass/Gelatin Scaffold in Critically Sized rabbit Calvarial Defects | ||
| Pathobiology Reserach | ||
| Article 5, Volume 22, Issue 3, 2019, Pages 141-147 PDF (1002.98 K) | ||
| Document Type: Original Research | ||
| Authors | ||
| N. Baheiraei* 1; A. Adeli Mehr2; H. Eyni2 | ||
| 1Hematology Department, Medical Sciences Faculty, Tarbiat Modares University, Tehran, Iran | ||
| 2Anatomical Sciences Department, Medical Sciences Faculty, Tarbiat Modares University, Tehran, Iran | ||
| Abstract | ||
| Aims: Growing experiments show that biomaterials that have a bioactive glass (BG) indicate encouraging effects on bone tissue repair. Strontium-substituted BGs (BG/Sr) have been confirmed to improve bone formation while preventing bone resorption by osteoclasts. Materials and Methods: This study aimed to evaluate the potential of strontium substitution on bioglass/gelatin (Gel) osteogenesis in critically sized rabbit calvarial defects. Defects were treated with Gel-BG or Gel-BG/Sr scaffolds and one defect was left unfilled as a control. Bone regeneration and mineralization process were evaluated by hematoxylin and eosin, Masson’s trichrome and Alizarin Red staining after 4 and 8 weeks post-implantation. Findings: Based on the histological findings, newly formed bone area in scaffolds containing BG/Sr was greater than that without Sr after 8 weeks. Conclusion: Our results specified that BG/Sr containing scaffolds could better increase bone regeneration than those without Sr and could be considered as a bone graft in bone tissue engineering. | ||
| Keywords | ||
| Tissue engineering; Bioactive; Strontium; Osteogenesis | ||
| References | ||
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