Sadeghizadeh, Majid, Erfani-Moghadam, Vahid, Nomani, Alireza, Najafi, Farhood, Yazdani, Yaghoub, Sadeghizadeh, Majid (2014). Design and Synthesis of a Novel Dendrosome and a PEGylated PAMAM Dendrimer Nanocarrier to Improve the Anticancer effect of Turmeric (Curcuma longa) Curcumin. , 17(1), 63-77.
Majid Sadeghizadeh; Vahid Erfani-Moghadam; Alireza Nomani; Farhood Najafi; Yaghoub Yazdani; Majid Sadeghizadeh. "Design and Synthesis of a Novel Dendrosome and a PEGylated PAMAM Dendrimer Nanocarrier to Improve the Anticancer effect of Turmeric (Curcuma longa) Curcumin". , 17, 1, 2014, 63-77.
Sadeghizadeh, Majid, Erfani-Moghadam, Vahid, Nomani, Alireza, Najafi, Farhood, Yazdani, Yaghoub, Sadeghizadeh, Majid (2014). 'Design and Synthesis of a Novel Dendrosome and a PEGylated PAMAM Dendrimer Nanocarrier to Improve the Anticancer effect of Turmeric (Curcuma longa) Curcumin', , 17(1), pp. 63-77.
Sadeghizadeh, Majid, Erfani-Moghadam, Vahid, Nomani, Alireza, Najafi, Farhood, Yazdani, Yaghoub, Sadeghizadeh, Majid Design and Synthesis of a Novel Dendrosome and a PEGylated PAMAM Dendrimer Nanocarrier to Improve the Anticancer effect of Turmeric (Curcuma longa) Curcumin. , 2014; 17(1): 63-77.

Design and Synthesis of a Novel Dendrosome and a PEGylated PAMAM Dendrimer Nanocarrier to Improve the Anticancer effect of Turmeric (Curcuma longa) Curcumin

Pathobiology Reserach
Article 6, Volume 17, Issue 1, 2014, Pages 63-77    PDF (2.55 M)
Authors
Majid Sadeghizadeh* 1; Vahid Erfani-Moghadam2; Alireza Nomani3; Farhood Najafi4; Yaghoub Yazdani5; Majid Sadeghizadeh* 1
1Department of Genetic, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
2Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
3Department of Pharmaceutics, Faculty of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
4Department of Resin and Additives, Institute for Color Science and Technology, Tehran, Iran
5Infectious Diseases Research Center and Laboratory Science Research Center, Golestan University of Medical Sciences, Gorgan, Iran
Abstract
Objective: In recent decades, the anticancer effect of curcumin has been proven by several studies. Curcumin affects multiple cell signaling pathways and prevents cell proliferation, invasion, metastasis and angiogenesis. However, the aqueous solubility of curcumin and its bioavailability are very low which restricts its anticancer properties. In this research, we have synthesized a monomethoxy poly (ethylene glycol)-Oleate (mPEG-OA) di-block copolymer and used a surface PEGylated poly (amidoamine) (PAMAM) dendrimer to improve bioavailability of curcumin in cancer cells. Methods: Thecritical micelle concentration (CMC) of mPEG-OA, drug loading efficiencies, and cytotoxicity in the human glioblastoma cell line (U87MG) of all the prepared nanodevices were thoroughly investigated. Results: Atomic force microscopy (AFM) and dynamic light scattering (DLS) studies have shown that mPEG-OA have two common nanostructures, micelles and polymerosomes. mPEG-OA micelles had a very low CMC (0.03 g/l). The IC50 of free curcumin (0.01 methanol solution) was 48 μM, curcumin-loaded mPEG-OA was 24 μM , and curcumin-loaded PAMAM dendrimer was 13 μM. Moreover, the PEGylated PAMAM was non-cytotoxic. Conclusion: The results indicated that by using these nanocarriers, the bioavailability of curcumin significantly increased compared to free curcumin. Overall, this research revealed that these curcumin nanocarriers could be considered as appropriate drug delivery systems for curcumin delivery in cancer cells.
Keywords
Dendrosome; Curcumin; Micelles; Polymersome; PAMAM dendrimers
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