Adekola, Hafeez, Ojo, David, Balogun, Saka, Dipeolu, Morenike, Mohammed, Musa, Amusan, Adeolu (2023). Seroprevalence of Zika Virus IgM Antibodies in Pregnant Woman in Nigeria. , 9(2), 179-190. doi: 10.61186/iem.9.2.179
Hafeez Adekola; David Ojo; Saka Balogun; Morenike Dipeolu; Musa Mohammed; Adeolu Amusan. "Seroprevalence of Zika Virus IgM Antibodies in Pregnant Woman in Nigeria". , 9, 2, 2023, 179-190. doi: 10.61186/iem.9.2.179
Adekola, Hafeez, Ojo, David, Balogun, Saka, Dipeolu, Morenike, Mohammed, Musa, Amusan, Adeolu (2023). 'Seroprevalence of Zika Virus IgM Antibodies in Pregnant Woman in Nigeria', , 9(2), pp. 179-190. doi: 10.61186/iem.9.2.179
Adekola, Hafeez, Ojo, David, Balogun, Saka, Dipeolu, Morenike, Mohammed, Musa, Amusan, Adeolu Seroprevalence of Zika Virus IgM Antibodies in Pregnant Woman in Nigeria. , 2023; 9(2): 179-190. doi: 10.61186/iem.9.2.179

Seroprevalence of Zika Virus IgM Antibodies in Pregnant Woman in Nigeria

Infection Epidemiology and Microbiology
Article 9, Volume 9, Issue 2, 2023, Pages 179-190    PDF (532.77 K)
Document Type: Original Research
DOI: 10.61186/iem.9.2.179
Authors
Hafeez Adekola* 1; David Ojo2; Saka Balogun2; Morenike Dipeolu3; Musa Mohammed4; Adeolu Amusan5
1Department of Microbiology, Olabisi Onabanjo University, Ago Iwoye, Ogun State, Nigeria
2Department of Microbiology, Federal University of Agriculture, Abeokuta, Ogun State, Nigeria
3Department of Veterinary Public Health and Reproduction, Federal University of Agriculture, Abeokuta, Ogun State, Nigeria
4Department of Medicine, Ahmadu Bello University, Zaria, Kaduna State, Nigeria
5Veterinary Teaching Hospital, Federal University of Agriculture, Abeokuta, Ogun State, Nigeria
Abstract
Backgrounds: In developing countries like Nigeria, screening of Zika virus (ZIKV) infection in pregnant women remains limited due to a lack of diagnostic facilities and non-specific symptoms, leading to potential misdiagnosis of the disease as other febrile illnesses such as malaria or typhoid.

Materials & Methods: To address this issue, this study aimed to investigate the prevalence of anti-ZIKV IgM antibodies in pregnant women using enzyme-linked immunoassay. Additionally, the quantitative reverse transcription polymerase chain reaction (RT-qPCR) assay targeted a specific region of the membrane protein (prM) gene to detect Zika virus presence in the collected serum samples. For a period of four months from December 2021 to March 2022, a total of 360 serum samples were collected from pregnant women attending antenatal care units in two tertiary hospitals located in different regions of Nigeria.

Findings: The results of this study revealed a prevalence of 17.2% (62 samples) for anti-ZIKV IgM antibodies among pregnant women. Further analysis using the RT-qPCR method detected Zika virus (prM gene) in 1.9% (7/62) of the serum samples. In addition to these virological results, the statistical analysis of sociodemographic data, clinical characteristics, and risk factors for ZIKV infection demonstrated a significant correlation between seropositivity and various factors including ethnicity, residence, occupation, and history of arboviral diseases (p< .005).

Conclusion: Given the potential consequences of ZIKV infection in pregnant women, early diagnosis and intervention could improve maternal outcomes and prevent fetal abnormalities.
Keywords
ZIKV; IgM; Pregnancy; Arboviruses
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