Keshavarz, Maryam, Khosravy, Farideh, Nikbin, Behrouz, Honarmand, Malektaj, Sarafnejad, Abdolfatah (2008). Study of IgE in children with Steroids Responsive Nephrosis. , 10(0), -.
Maryam Keshavarz; Farideh Khosravy; Behrouz Nikbin; Malektaj Honarmand; Abdolfatah Sarafnejad. "Study of IgE in children with Steroids Responsive Nephrosis". , 10, 0, 2008, -.
Keshavarz, Maryam, Khosravy, Farideh, Nikbin, Behrouz, Honarmand, Malektaj, Sarafnejad, Abdolfatah (2008). 'Study of IgE in children with Steroids Responsive Nephrosis', , 10(0), pp. -.
Keshavarz, Maryam, Khosravy, Farideh, Nikbin, Behrouz, Honarmand, Malektaj, Sarafnejad, Abdolfatah Study of IgE in children with Steroids Responsive Nephrosis. , 2008; 10(0): -.

Study of IgE in children with Steroids Responsive Nephrosis

Pathobiology Reserach
Article 1, Volume 10, Issue 0, 2008    PDF (226.57 K)
Authors
Maryam Keshavarz* 1; Farideh Khosravy2; Behrouz Nikbin1; Malektaj Honarmand3; Abdolfatah Sarafnejad4
1Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
3Department of Nephrology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4Department of Immunology, Tehran University of Medical Sciences, Tehran, Iran
Abstract
Objectives: The idiopathic minimal change nephritic syndrome (nephrosis) is responsible in 80% of nephritic syndromes in children. It is a clinical entity characterized by inter and outer renal parameters. Main factor in glomerolar damages is proteinuria and the role of IgE is possible. Aim: In this research, serum IgE concentrations were measured in children with nephrosis in three stages: Relapse, Remission in treatment with steroids, Remissions after treatment with steroids.
Materials and methods: Study was done on children under 16 years old that suffered from nephrosis. They treated with Prednisolone. Serum IgE concentrations were measured by ELISA technique.
Results: Average Concentration of serum IgE in the relapse phase was 274.8 Iu/ml (SD=14.6); It was in the remission with steroids treatments 179.59 Iu/ml (SD= 14.82) and it was 234. 9 Iu/ml (SD=14.58) in the remission phase after treatment with steroids.
Conclusion: In some cases IgE is significantly reduced after steroid treatment therefore it seems possible that allergic agents can trigger or increase the disease. Serum IgE concentration was not a main factor in nephritic syndrome.
Keywords
IgE; Idiopathic minimal change nephrotic syndrome
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