Sabet Sarvestani, Amir, Abdolmaleki, Parviz, Mowla, Seyed Javad, Ghanati, Faezeh, Tavassoli, Zeinab, Heshmati, Emran (2008). Study the effects of static magnetic field on cell cycle progression in mesenchymal bone marrow stem cells of rat. , 11(0), 9-18.
Amir Sabet Sarvestani; Parviz Abdolmaleki; Seyed Javad Mowla; Faezeh Ghanati; Zeinab Tavassoli; Emran Heshmati. "Study the effects of static magnetic field on cell cycle progression in mesenchymal bone marrow stem cells of rat". , 11, 0, 2008, 9-18.
Sabet Sarvestani, Amir, Abdolmaleki, Parviz, Mowla, Seyed Javad, Ghanati, Faezeh, Tavassoli, Zeinab, Heshmati, Emran (2008). 'Study the effects of static magnetic field on cell cycle progression in mesenchymal bone marrow stem cells of rat', , 11(0), pp. 9-18.
Sabet Sarvestani, Amir, Abdolmaleki, Parviz, Mowla, Seyed Javad, Ghanati, Faezeh, Tavassoli, Zeinab, Heshmati, Emran Study the effects of static magnetic field on cell cycle progression in mesenchymal bone marrow stem cells of rat. , 2008; 11(0): 9-18.

Study the effects of static magnetic field on cell cycle progression in mesenchymal bone marrow stem cells of rat

Pathobiology Reserach
Article 3, Volume 11, Issue 0, 2008, Pages 9-18    PDF (314.28 K)
Authors
Amir Sabet Sarvestani1; Parviz Abdolmaleki* 2; Seyed Javad Mowla3; Faezeh Ghanati4; Zeinab Tavassoli1; Emran Heshmati2
1of Biophysics, Faculty of Basic Sciences, Tarbiat Modares University, Tehran, Iran
2Department of Biophysics, Faculty of Basic Sciences, Tarbiat Modares University, Tehran, Iran
3Department of Genetics, Faculty of Basic Sciences, Tarbiat Modares University, Tehran, Iran
4Department of Plants Biology, Faculty of Basic Sciences, Tarbiat Modares University, Tehran, Iran
Abstract
Objective: The environmental exposure to Magnetic Fields (MFs) may interact with biological systems. MFs are generated from various sources such as power lines, electric appliances at homes and offices, electrified transportation systems including urban railway systems and diagnostic devices such as Magnetic Resonance Imaging (MRI). There are some scientific evidences that imply the exposure to MFs are hazardous to our health and increases the rate of some cancers like leukemia. The biological consequences of exposure to MFs have been investigated from a variety of endpoints. However, most studies have been performed in vitro and have examined effects on cellular processes and its malfunction; such studies can be used as evidence of effects in vivo.
Materials and Methods: In this study Bone Marrow Stem Cells were grown in the absence and in the presence of a 15 mT Static Magnetic Field for 5 hours in order to determine any changes in cell cycle progression using the count of cells in different phases. The count of cells in a special phase of cell cycle indicates the length of that phase. The Static Magnetic Field was performed using a locally designed MF generator.
Results: A significant increase in the number of cells in G0/G1 was observed in comparison with the controls. Also the number of cells in G0/G1 in the cells treated with Hydrogen-Peroxide, as an oxidative agent, was significantly increased in Static MF.
Conclusion: Genetic material damages or mal-function of related proteins may cause these halts. Mfs have not enough energy to affect the biological molecules directly but the mechanism of free radical mediators is probable. These kinds of damages (direct or indirect) can permanently bring the cell cycle to a halt.
Keywords
Mesenchymal stem cells; Static magnetic field; Cell cycle progression epithelium and stroma involve in the invasion of embryo
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