Kazemi Arababadi, Mohammad, Pourfathollah, Ali Akbar, Jafarzadeh, Abdollah, Hassanshahi, Gholamhossein, Afrooz, Mohammad Reza, Hadadian, Mahmood (2008). Occult HBV infection in Rafsanjanese blood donors. , 11(0), 1-7.
Mohammad Kazemi Arababadi; Ali Akbar Pourfathollah; Abdollah Jafarzadeh; Gholamhossein Hassanshahi; Mohammad Reza Afrooz; Mahmood Hadadian. "Occult HBV infection in Rafsanjanese blood donors". , 11, 0, 2008, 1-7.
Kazemi Arababadi, Mohammad, Pourfathollah, Ali Akbar, Jafarzadeh, Abdollah, Hassanshahi, Gholamhossein, Afrooz, Mohammad Reza, Hadadian, Mahmood (2008). 'Occult HBV infection in Rafsanjanese blood donors', , 11(0), pp. 1-7.
Kazemi Arababadi, Mohammad, Pourfathollah, Ali Akbar, Jafarzadeh, Abdollah, Hassanshahi, Gholamhossein, Afrooz, Mohammad Reza, Hadadian, Mahmood Occult HBV infection in Rafsanjanese blood donors. , 2008; 11(0): 1-7.

Occult HBV infection in Rafsanjanese blood donors

Pathobiology Reserach
Article 1, Volume 11, Issue 0, 2008, Pages 1-7    PDF (205.51 K)
Authors
Mohammad Kazemi Arababadi* 1; Ali Akbar Pourfathollah2; Abdollah Jafarzadeh3; Gholamhossein Hassanshahi4; Mohammad Reza Afrooz5; Mahmood Hadadian5
1Instructor, Department of Microbiology, Immunology and Hematology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
2Professor, Department of Immunology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
3Associated Professor, Department of Immunology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
4Assistant Professor, Department of Hematology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
5B.Sc., Iranian Blood Transfusion Organization, Rafsanjan Center, Rafsanjan, Iran
Abstract
Objective: Occult hepatitis B infection is a form of hepatitis in which despite of absence of detectable HBsAg, HBV-DNA is present in peripheral blood of patients. This clinical form of B hepatitis creates some problems for the Iranian blood transfusion services. Therefore, the aim of this study was the evaluation of status of occult hepatitis B infection in the Rafsanjanese blood donors.
Materials and Methods: In this cross-sectional study, total of 3700 blood donor samples were collected and tested for HBsAg and anti-HBs using ELISA. The HBsAg negative and anti-HBc positive samples were selected and screened for HBV-DNA using PCR.
Results: Results of current study indicated that 352 (9.5%) of 3700 blood samples were HBsAg– and anti-HBc+. HBV-DNA was detected in 57 (16.1% of HBsAg– and anti-HBc+ and 1.54% of total samples) samples.
Conclusion: Results of this study are in agreement with our previous studies in the prevalence of OBI. Therefore, it seems that occult hepatitis B infection rate is high in the Iranian blood donors and probably is one of the main causes of post-transfusion hepatitis.
Keywords
HBV-DNA; HBsAg; anti-HBc; Occult hepatitis B infection
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