Nasiraei-Moghadam, Shiva, Parivar, Kazem, Ahmadiani, Abolhasan, Movahedin, Mansoureh, Vaez-Mahdavi, Mohamad Reza, Roughani, Mehrdad, Kazeminejad, Behrang (2012). Study of the Therapeutic Effect of Melatonin after Food Deprivation in Apoptosis and Oxidative Stress in Rat Testis. , 15(3), 79-93.
Shiva Nasiraei-Moghadam; Kazem Parivar; Abolhasan Ahmadiani; Mansoureh Movahedin; Mohamad Reza Vaez-Mahdavi; Mehrdad Roughani; Behrang Kazeminejad. "Study of the Therapeutic Effect of Melatonin after Food Deprivation in Apoptosis and Oxidative Stress in Rat Testis". , 15, 3, 2012, 79-93.
Nasiraei-Moghadam, Shiva, Parivar, Kazem, Ahmadiani, Abolhasan, Movahedin, Mansoureh, Vaez-Mahdavi, Mohamad Reza, Roughani, Mehrdad, Kazeminejad, Behrang (2012). 'Study of the Therapeutic Effect of Melatonin after Food Deprivation in Apoptosis and Oxidative Stress in Rat Testis', , 15(3), pp. 79-93.
Nasiraei-Moghadam, Shiva, Parivar, Kazem, Ahmadiani, Abolhasan, Movahedin, Mansoureh, Vaez-Mahdavi, Mohamad Reza, Roughani, Mehrdad, Kazeminejad, Behrang Study of the Therapeutic Effect of Melatonin after Food Deprivation in Apoptosis and Oxidative Stress in Rat Testis. , 2012; 15(3): 79-93.

Study of the Therapeutic Effect of Melatonin after Food Deprivation in Apoptosis and Oxidative Stress in Rat Testis

Pathobiology Reserach
Article 7, Volume 15, Issue 3, 2012, Pages 79-93    PDF (6.47 M)
Authors
Shiva Nasiraei-Moghadam* 1; Kazem Parivar2; Abolhasan Ahmadiani3; Mansoureh Movahedin4; Mohamad Reza Vaez-Mahdavi5; Mehrdad Roughani6; Behrang Kazeminejad7
1Ph.D. Candidate, Department of Biology, Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
2Professor, Department of Biology, Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
3Professor, Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4Professor, Department of Anatomy, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
5Professor, Clinical Trial Iranian Traditional Medicine Research Center & Department of Health Equity, Shahed University, Tehran, Iran
6Professor in physiology,Neuroscience research center, Medicine Shahed University, Tehran, Iran
7Assistant Professor, Department of Pathology, Modares Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract
Objective: The goals of the study are evaluation the effect(s) of food deprivation as a social stress on testis structure. We also investigated the effects of melatonin treatment as an antioxidant component and inequality on the effect(s) of food deprivation. Methods: We investigated the improving effects of melatonin and social stress (food deprivation) on 42 male rats in 7 groups including control, sham, melatonin received (M), food deprivation (1/3 of control daily food) plus observation (FD), FD + melatonin (FDM), isolated FD (FDi), and FDi + melatonin (FDMi) groups. After 14 days, rats' testes were studied using immuno histochemistry and TUNEL assays to determine the number of apoptotic cells. Biochemical evaluation was taken on malodialdehide (MDA) and glutathione (GSH). ANOVA and Tukey's tests were done to analyse the data. PResults: The results of sham group was declined for similarity to results of control group. In FD group, MDA was increased significantly (PConclusion: Food deprivation can induce oxidative stress which is associated with increasment of apoptotic cells in testis. Isolation can compensate these effects. These results refer to inequality. Since melatonin is recognized for its anti-oxidative and improving effects, we have shown involvement of oxidative stress mechanisms on the stress of food deprivation with inequality.
Keywords
Apoptosis; Food deprivation; Melatonin; Testis; Inequality
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