Antinociceptive Effect of Curcumin, an Effective Constituent of Turmeric, in Diabetic Rats and Evaluation of the Involvement of Lipid Peroxidation | ||
| Pathobiology Reserach | ||
| Article 3, Volume 15, Issue 1, 2012, Pages 23-32 PDF (1.2 M) | ||
| Authors | ||
| Mehrdad Roghani* 1; Tourandokht Baluchnejadmojarad2 | ||
| 11- Neurophysiology Research Center, Shahed University, Tehran, Iran 2- Department of Physiology, Faculty of Medicine, Shahed University, Tehran, Iran | ||
| 2Professor, Department of Physiology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran | ||
| Abstract | ||
| Objective: This study was designed to investigate the antinociceptive effect of curcumin in diabetic rats by using the formalin and hot tail immersion tests. Methods: Wistar rats were divided into the following six groups: control; curcumin-treated control (50 mg/kg); diabetic; sodium salicylate (SS)-treated diabetic; and two curcumin-treated diabetic groups (10 and 50 mg/kg). Curcumin was administered seven days after streptozotocin injection for a total of five weeks. Results: High-dose curcumin treatment of diabetic rats reduced the pain score in both acute and chronic phases of the formalin test (p<0.05). SS-treated diabetic rats had a reduction in pain score only in the chronic phase of the formalin test (p<0.05). In the hot tail immersion test, diabetic rats showed a significant reduction in tail flick latency compared to the control group (p<0.01). High-dose curcumin treated diabetic rats showed significantly increased latency relative to untreated diabetic rats (p<0.05). Diabetic rats also showed a significant increase in the tissue level of malondialdehyde (MDA; p<0.01). High-dose curcumin treated diabetic rats had a significantly reduced level of MDA (p<0.05). Conclusion: Chronic administration of curcumin could attenuate the nociceptive score in both the acute and chronic phases of the formalin test in a streptozotocin-induced experimental model of diabetes mellitus and increase thermal pain threshold. The beneficial effect of curcumin is partly attributed to attenuation of lipid peroxidation in the periphery. | ||
| Keywords | ||
| Diabetes mellitus; Pain; Curcumin; lipid peroxidation | ||
| References | ||
|
| ||
|
Statistics Article View: 118 PDF Download: 76 |
||
| Number of Journals | 45 |
| Number of Issues | 2,196 |
| Number of Articles | 24,880 |
| Article View | 28,801,940 |
| PDF Download | 18,606,084 |