khoshzaban, Fariba, Ghaffarifar, Fatemeh, Mahmmoudzadeh Poornaki, Abbas, Ghazanfari, Tooba, Naseri, Mohsen, Khmesipoor, Ali, Naeini, Alireza, Mojabi, Fatemeh-Sadat (2011). Evaluation treatment of cutaneous Leishmaniasis with Garlic extract and R10 fraction in BALB/c, C57BL/6 and outbred SW mice. , 14(3), 25-34.
Fariba khoshzaban; Fatemeh Ghaffarifar; Abbas Mahmmoudzadeh Poornaki; Tooba Ghazanfari; Mohsen Naseri; Ali Khmesipoor; Alireza Naeini; Fatemeh-Sadat Mojabi. "Evaluation treatment of cutaneous Leishmaniasis with Garlic extract and R10 fraction in BALB/c, C57BL/6 and outbred SW mice". , 14, 3, 2011, 25-34.
khoshzaban, Fariba, Ghaffarifar, Fatemeh, Mahmmoudzadeh Poornaki, Abbas, Ghazanfari, Tooba, Naseri, Mohsen, Khmesipoor, Ali, Naeini, Alireza, Mojabi, Fatemeh-Sadat (2011). 'Evaluation treatment of cutaneous Leishmaniasis with Garlic extract and R10 fraction in BALB/c, C57BL/6 and outbred SW mice', , 14(3), pp. 25-34.
khoshzaban, Fariba, Ghaffarifar, Fatemeh, Mahmmoudzadeh Poornaki, Abbas, Ghazanfari, Tooba, Naseri, Mohsen, Khmesipoor, Ali, Naeini, Alireza, Mojabi, Fatemeh-Sadat Evaluation treatment of cutaneous Leishmaniasis with Garlic extract and R10 fraction in BALB/c, C57BL/6 and outbred SW mice. , 2011; 14(3): 25-34.

Evaluation treatment of cutaneous Leishmaniasis with Garlic extract and R10 fraction in BALB/c, C57BL/6 and outbred SW mice

Pathobiology Reserach
Article 3, Volume 14, Issue 3, 2011, Pages 25-34    PDF (273.05 K)
Authors
Fariba khoshzaban* 1; Fatemeh Ghaffarifar2; Abbas Mahmmoudzadeh Poornaki3; Tooba Ghazanfari4; Mohsen Naseri5; Ali Khmesipoor6; Alireza Naeini7; Fatemeh-Sadat Mojabi8
1Assistant Professor, Department of Parasitology and Mycology, Shahed University, Tehran, Iran Medicinal Plants Research Center, Shahed University, Tehran, Iran
2Associated Professor, Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
3Professor, Department of Parasitology, Faculty of Medical Sciences, Baghiyatallah University, Tehran, Iran
4Professor, Department of Immunology, Faculty of Medicine, Shahed University, Tehran, Iran
5Associated Professor, Traditional Iranian Medicine Clinical Trail Research Center, Shahed University, Tehran, Iran
6Professor, Center for Research & Training in Skin Diseases & Leprosy (CRTSDL), Tehran University, Tehran, Iran
7Assistant Professor, Department of Parasitology and Mycology, Shahed University, Tehran, Iran
8M.D., Shahed University, Tehran, Iran
Abstract
Objective: Leishmaniasis is one of the six most common parasitic infections in tropical regions. There are different therapeutic modalities. However therapeutic resistance is developed and resulted in numerous problems. So evaluation of other therapeutic modalities is performed extensively. We compared the therapeutic response of cutaneous leishmaniasis with Glucantime and Garlic extract and it'R10 in animal model.
Materials and Methods: This experimental study was conducted in Shahed University. The therapeutic response of cutaneous leishmaniasis to Glucantime and Garlic extract and R10 in animal model was studied in BALB/c, outbred SW mice and C57BL/6 mice. These three races were divided in four groups according to receiving either one of these three agents or no treatment (control). The therapeutic response was evaluated according to parasitic load before and after treatment and also with measuring the size of the lesions.
Results: The results showed that R10 had good therapeutic efficacy in treatment of lesions in mice (P<0.05) that this efficacy was significant in sixth, seventh and eighth weeks after the treatment. There was also a statistically significant difference between the groups regarding the parasitic load (P<0.05).
Conclusion: According to the results, it may be concluded that R10 extract would have a good efficacy in treatment of cutaneous leishmaniasis that is comparable with glucantime.
Keywords
Cutaneous Leishmaniasis; Animal model; garlic extract; R10 fraction
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