Asheghabadi, Mahdiye, Bigdeli, Mohammad Reza (2011). The role of oxygen radicals-scavenger in neuroprotection-induced by normobaric hyperoxia on infarct volume in the rat brain. , 14(2), 75-82.
Mahdiye Asheghabadi; Mohammad Reza Bigdeli. "The role of oxygen radicals-scavenger in neuroprotection-induced by normobaric hyperoxia on infarct volume in the rat brain". , 14, 2, 2011, 75-82.
Asheghabadi, Mahdiye, Bigdeli, Mohammad Reza (2011). 'The role of oxygen radicals-scavenger in neuroprotection-induced by normobaric hyperoxia on infarct volume in the rat brain', , 14(2), pp. 75-82.
Asheghabadi, Mahdiye, Bigdeli, Mohammad Reza The role of oxygen radicals-scavenger in neuroprotection-induced by normobaric hyperoxia on infarct volume in the rat brain. , 2011; 14(2): 75-82.

The role of oxygen radicals-scavenger in neuroprotection-induced by normobaric hyperoxia on infarct volume in the rat brain

Pathobiology Reserach
Article 7, Volume 14, Issue 2, 2011, Pages 75-82    PDF (497.23 K)
Authors
Mahdiye Asheghabadi1; Mohammad Reza Bigdeli* 2
1M.Sc., Department of Physiology, Faculty of Biological Sciences, Beheshti University, Iran
2Asisstant Professor, Department of Physiology, Faculty of Biological Sciences, Beheshti University, Iran
Abstract
Objective: Recent studies have shown that the use of prolonged and intermittent normobaric hyperoxia (95%) decrease the infarct volume of stroke. The aim of current study was to study the effect of an oxygen radicals-scavenger applied during intermittent normobaric hyperoxia on infarct volume in the rat brain and neurologic deficit.
Materials and Methods: Male Wistar rats (250-350 g) were divided to two main groups. These groups were respectively subjected to room air (21% O2; RA) or normobaric hyperoxia (95% O2; HO) 4 hours per day for 6 days. Each main group was divided to three subgroups which received nothing (RA and HO), normal saline (HO-S and RA-S) or Dimethyltiourea (HO-MT and RA-MT. Afterward, all rats were subjected to 60 min middle cerebral artery occlusion (MCAO). After 24 h, neurologic deficit scores and infarct volume were assessed.
Results: The medians of neurologic deficit scores in RA, RA-MT, RA-S, HO-MT, HO-S, and HO were 2, 2, 2, 2, 0, 0, respectively. The infarct volume in RA, RA-MT, RA-S, and HO-MT versus HO-S, and HO were increased. Above results showed that neurologic deficit score and infarct volume were restored by MT significantly.
Conclusion: The effective neuroprotection induced by intermittent normobaric hyperoxia seems to be mediated at least partially by oxygen radicals.
Keywords
Normobaric Hyperoxia; stroke; Neuroprotection; Neurologic Deficit; Free Radical Oxygen
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