Haghighi, Farnoosh, Roudbar Mohammadi, Shahla, Soleimani, Neda, Sattari, Morteza (2011). Evaluation of antifungal activity of essential oils of Thymus vulgaris, Petroselinum Crispum, Cuminum cyminum and Bunium persicum on candida albicans in comparison with Fluconazole. , 14(1), 29-35.
Farnoosh Haghighi; Shahla Roudbar Mohammadi; Neda Soleimani; Morteza Sattari. "Evaluation of antifungal activity of essential oils of Thymus vulgaris, Petroselinum Crispum, Cuminum cyminum and Bunium persicum on candida albicans in comparison with Fluconazole". , 14, 1, 2011, 29-35.
Haghighi, Farnoosh, Roudbar Mohammadi, Shahla, Soleimani, Neda, Sattari, Morteza (2011). 'Evaluation of antifungal activity of essential oils of Thymus vulgaris, Petroselinum Crispum, Cuminum cyminum and Bunium persicum on candida albicans in comparison with Fluconazole', , 14(1), pp. 29-35.
Haghighi, Farnoosh, Roudbar Mohammadi, Shahla, Soleimani, Neda, Sattari, Morteza Evaluation of antifungal activity of essential oils of Thymus vulgaris, Petroselinum Crispum, Cuminum cyminum and Bunium persicum on candida albicans in comparison with Fluconazole. , 2011; 14(1): 29-35.

Evaluation of antifungal activity of essential oils of Thymus vulgaris, Petroselinum Crispum, Cuminum cyminum and Bunium persicum on candida albicans in comparison with Fluconazole

Pathobiology Research
Article 3, Volume 14, Issue 1, 2011, Pages 29-35    PDF (263.66 K)
Authors
Farnoosh Haghighi1; Shahla Roudbar Mohammadi* 2; Neda Soleimani3; Morteza Sattari4
1., Department of Mycology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran14115_331
2Assistant Professor, Department of Mycology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IranP.O. Box: 14115_331 P.O.Code: 1411713116
3Department of Bacteriology, School of Medical Sciences, Tarbiat Modares University
4Associated Professor, Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
Abstract
Objective: Nowadays notable increase in acquired resistance of Candida species to antifungal drugs and necessity of using agents with antifungal properties is unavoidable. In some plants due to presence of components such as polyphenols have antimicrobial properties. In this study antifungal effects of essential oils of Thymus vulgaris, Petroselinum crispum, Cuminum cyminum and Bunium persicum on standard strain of Candida albicans were evaluated.
Materials and Methods: 25 grams leafs of the Thymus vulgaris and Petroselinum crispum and seeds of the Cuminum cyminum and Bunium persicum were dried and grinded after that the essential oils of each mentioned plant were prepared by Clevenger system. Serial dilutions of essential oils were made in 96 well microtiter plates. Minimum Inhibitory Concentration (MIC) and Inhibitory zone diameter were assessed by Microdilution broth and Disc diffusion agar techniques, MIC50, MIC90 and MFC were also determined.
Results: Minimum inhibitory concentration 90(MIC90) essential oils of Thymus vulgaris, Petroselinum crispum, Cuminum cyminum and Bunium persicum were respectively 25, 72, 412, 130 µg/ml and Minimal Fungicide Concentration (MFC) were 48, 146, 62, 280. Inhibitory zone diameters were 28, 20, 12, 15 millimetres.
Conclusion: In this evaluation essential oils of Thymus vulgaris, Petroselinum crispum, Cuminum cyminum and Bunium persicum showed suitable antifungal effects against growth of standard strain of Candida albicans. Thus these herbal essences after supplementary studies possibly can be suitable substitute for chemical medicine on Candida infections especially on mucocutaneous Candidiasis.
Keywords
Antifungal effects; Candida albicans; herbal essences; Fluconazole
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