Study role of age in contact dependent transmission of Mycobacterium tuberculosis in northwest of Iran by IS6110-RFLP method | ||
| Pathobiology Reserach | ||
| Article 1, Volume 12, Issue 1, 2009, Pages 11-16 PDF (126.02 K) | ||
| Authors | ||
| محمد اصغرزاده* ; عباس علی بخشی; جواد رنجبری; غلامرضا حنیفی; ایرج خلیلی; ناصر رزمآرایی | ||
| Abstract | ||
| Objective: The present study investigated the role in transmission of M. tuberculosis strains isolated from tuberculosis patients residing in Northwest (East and West Azarbaijan) of Iran. Materials and Methods: We performed restriction fragment length polymorphism analysis on IS6110 of M. tuberculosis isolated from Northwest Iran. Total of 165 isolates of M. tuberculosis were analyzed by RFLP method. Results: The 5 copies and more IS6110 isolates comprised 30.52% of the total isolates. They formed 16 clustered groups consisting of 2 to 10 cases each. 69.48% of patients had a unique RFLP patterns. Cases from male patients were more clustered than female patients but statistically was not significant (P>0.05). In this study patients with 56 and older age were strongly associated with clustering (59.6%), which were significantly more than younger patients (P<0.05). Conclusion: In the present study we found old age as a major risk factor in contact dependent transmission of TB compared to disease recurrence. Unemployment and poor living condition were also among the risk factors in transmission of tuberculosis. | ||
| Keywords | ||
| IS6110; RFLP; Mycobacterium tuberclosis; Age; Transmission | ||
|
Statistics Article View: 113 PDF Download: 41 |
||
| Number of Journals | 45 |
| Number of Issues | 2,171 |
| Number of Articles | 24,674 |
| Article View | 24,448,439 |
| PDF Download | 17,555,309 |