Maleki Ravasan, Naseh, Natanzian Ghahfarkhi, Marzie, Ali Oshaghi, Mohammad, Sattari, Morteza, Javadian, Ezzatodin, Yadegari, Mohammad Hossein, Rassi, Yavar, Goudarzi, Gholam Reza, Mohebali, Mehdi, Saharkhiz, Mohammad Jamal, Sadrai, Javid, Zarei, Zabihallah, Mohtarami, Fatemeh (2008). Antifungal activity of essential oil and alcoholic extract of Carum copticum against fluconazole-resistant and susceptible Candida albicans isolated. , 11(0), -.
Naseh Maleki Ravasan; Marzie Natanzian Ghahfarkhi; Mohammad Ali Oshaghi; Morteza Sattari; Ezzatodin Javadian; Mohammad Hossein Yadegari; Yavar Rassi; Gholam Reza Goudarzi; Mehdi Mohebali; Mohammad Jamal Saharkhiz; Javid Sadrai; Zabihallah Zarei; Fatemeh Mohtarami. "Antifungal activity of essential oil and alcoholic extract of Carum copticum against fluconazole-resistant and susceptible Candida albicans isolated". , 11, 0, 2008, -.
Maleki Ravasan, Naseh, Natanzian Ghahfarkhi, Marzie, Ali Oshaghi, Mohammad, Sattari, Morteza, Javadian, Ezzatodin, Yadegari, Mohammad Hossein, Rassi, Yavar, Goudarzi, Gholam Reza, Mohebali, Mehdi, Saharkhiz, Mohammad Jamal, Sadrai, Javid, Zarei, Zabihallah, Mohtarami, Fatemeh (2008). 'Antifungal activity of essential oil and alcoholic extract of Carum copticum against fluconazole-resistant and susceptible Candida albicans isolated', , 11(0), pp. -.
Maleki Ravasan, Naseh, Natanzian Ghahfarkhi, Marzie, Ali Oshaghi, Mohammad, Sattari, Morteza, Javadian, Ezzatodin, Yadegari, Mohammad Hossein, Rassi, Yavar, Goudarzi, Gholam Reza, Mohebali, Mehdi, Saharkhiz, Mohammad Jamal, Sadrai, Javid, Zarei, Zabihallah, Mohtarami, Fatemeh Antifungal activity of essential oil and alcoholic extract of Carum copticum against fluconazole-resistant and susceptible Candida albicans isolated. , 2008; 11(0): -.

Antifungal activity of essential oil and alcoholic extract of Carum copticum against fluconazole-resistant and susceptible Candida albicans isolated

Pathobiology Reserach
Article 2, Volume 11, Issue 0, 2008    PDF (366.71 K)
Authors
Naseh Maleki Ravasan1; Marzie Natanzian Ghahfarkhi2; Mohammad Ali Oshaghi3; Morteza Sattari* 4; Ezzatodin Javadian5; Mohammad Hossein Yadegari6; Yavar Rassi7; Gholam Reza Goudarzi8; Mehdi Mohebali9; Mohammad Jamal Saharkhiz10; Javid Sadrai11; Zabihallah Zarei12; Fatemeh Mohtarami13
1M.Sc., Department of Parasitology and Medical Entomology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
2M.Sc, Department of Medical Mycology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
3- Associate Professor, Department of Medical Entomology and Vector Control, Faculty of Health, Tehran University of Medical Sciences, Tehran, Iran
4Associated Professor, Department of Medical Bacteriology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
5- Professor, Department of Medical Entomology and Vector Control, Faculty of Health, Tehran University of Medical Sciences, Tehran, Iran
6Assistant Professor, Department of Medical Mycology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
7Professor, Department of Medical Entomology and vector Control, Faculty of Health, Tehran University of Medical Sciences, Tehran, Iran
8Ph.D. Student, Department of Bacteriology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
9Professor, Department of Parasitology and Mycology, Faculty of Health , Tehran University of Medical Sciences, Tehran, Iran
10Assistant professor, Department of Horticulture, Faculty of Agriculture, Shiraz University, Shiraz, Iran
11Assistant Professor, Department of Medical Parasitology and Entomology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
12M.Sc., Department of Parasitology and Mycology, Faculty of Health, Tehran University of Medical Sciences, Tehran, Iran
13Instructor, Department of Medical Entomology and Vector Control, Faculty of Health, Tehran University of Medical Sciences, Tehran, Iran
Abstract
Objective: Ajowan is an annual herbaceous essential oil of Carum copticom. The main components of the oil are Tymol, β-pinene, γ- terpinene and Sabinene.The fruit oil of Carum copticum has been reported to have several therapeutic effects including anti fungal, anti bacterial and anti viral,... Candida albicans is an opportunistic fungus and transforms into pathogenic form in favorable conditions, causing fungal diseases.
Materials and Methods: In this study, essential oil and alcoholic extract of Carum copticum were gained and Microdilution Broth method were used for detection of minimum inhibition concentration (MIC) and minimum fungicide concentration (MFC) of 11 clinical isolates of Candida albicans and Standard strain (PTCC50-27).
Results: Results show that MIC for essential oil is 0.43 µg/ml, 0.87 µg/ml and for alcoholic extract is 3.51 µg/ml, 7.03 µg/ml, 1/75 µg/ml. Thus, it seems that Carum copticum could inhibit Candida albicans growth by a similar mechanism which occurs by Fluconazole (FLZ). In general, the results obtained in this study indicate that Carum copticum has potential values for growth inhibition of Candida albicans in vitro.
Conclution: In recent years, systemic fungal infections due to Candida species have been received major consideration about inducing mortality in nosocomial patients because of increasing in immunocompromised disorders such as AIDS and hematological disorders as well as long term use of
Phlebotomus perfiliewi transcaucasicus sandflies.
Conclusion: This is the first report on natural infection of sand flies to L. donovani in the country and since the ecology and biology of L. donovani differs extensively from L. infantum, it is necessary to perform further studies to highlight the role of L. donovani in epidemiology of VL in the region and country.
Keywords
rDNA; Kala-azar (VL); Sand fly; Kinetoplast DNA; CPB
Statistics
Article View: 125
PDF Download: 73
Statistics
Number of Journals45
Number of Issues2,171
Number of Articles24,674
Article View24,431,413
PDF Download17,549,925