Rahimzadeh, Maral, Sadeghizadeh, Majid, Sadeghizadeh, Majid, Najafi, Farhood, Arab, Seyed Shahriar, Mobasheri, Hamid (2016). Study of Loading, Cytotoxicity, Uptake, and Release of Curcumin from a Novel Gemini Surfactant Nanocarrier. , 19(1), 13-27.
Maral Rahimzadeh; Majid Sadeghizadeh; Majid Sadeghizadeh; Farhood Najafi; Seyed Shahriar Arab; Hamid Mobasheri. "Study of Loading, Cytotoxicity, Uptake, and Release of Curcumin from a Novel Gemini Surfactant Nanocarrier". , 19, 1, 2016, 13-27.
Rahimzadeh, Maral, Sadeghizadeh, Majid, Sadeghizadeh, Majid, Najafi, Farhood, Arab, Seyed Shahriar, Mobasheri, Hamid (2016). 'Study of Loading, Cytotoxicity, Uptake, and Release of Curcumin from a Novel Gemini Surfactant Nanocarrier', , 19(1), pp. 13-27.
Rahimzadeh, Maral, Sadeghizadeh, Majid, Sadeghizadeh, Majid, Najafi, Farhood, Arab, Seyed Shahriar, Mobasheri, Hamid Study of Loading, Cytotoxicity, Uptake, and Release of Curcumin from a Novel Gemini Surfactant Nanocarrier. , 2016; 19(1): 13-27.

Study of Loading, Cytotoxicity, Uptake, and Release of Curcumin from a Novel Gemini Surfactant Nanocarrier

Pathobiology Reserach
Article 2, Volume 19, Issue 1, 2016, Pages 13-27    PDF (2.66 M)
Authors
Maral Rahimzadeh1; Majid Sadeghizadeh* 2; Majid Sadeghizadeh* 2; Farhood Najafi3; Seyed Shahriar Arab4; Hamid Mobasheri5
1Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
2Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
3Department of Resin and Additives, Institute for Color Science and Technology, Tehran, Iran
4Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
5Laboratory of Membrane Biophysics, Institute of Biochemistry and Biophysics, Tehran University, Tehran, Iran
Abstract
Objective: Numerous researches have been conducted to comprehend the anti-cancer effects of curcumin (Cu). Although the anti-proliferative properties of Cu on cancerous cells is known, the clinical application of this gold substrate is limited. This limitation is mostly due to low solubility, inefficient bioavailability, rapid metabolism, and improper uptake. In this study, we have synthesized a novel biodegradable gemini surfactant (Gs), after which the curcumin (Cu) molecules were encapsulated within the polymer to overcome its physicochemical limitations.
Methods: We prepared Gs-Cu nanoparticles by the nanoprecipitation method. Size and polydispersity index of the nanoparticles were determined by the dynamic light scattering (DLS) technique. The release profile of Cu from the polymer matrix was studied, and the MTT assay and cellular uptake of Gs-Cu on MDA-MB-231 cells were investigated in vitro.
Results: The Gs polymer had the capability to form polymersomes in an aqueous solution; a narrow size distribution was obtained (PDI≅0.3). The encapsulation efficiency approximated 87%. We observed a sustained release profile due to incorporation of Cu into the polymer matrix. The Gs-Cu complex showed more cytotoxicity compared to free Cu because of the higher rate of cellular internalization.
Conclusions: The data indicate that Gs polymersomes can be regarded as nanocarriers for hydrophobic curcumin molecules.
Keywords
Curcumin; Anti-cancer; Gemini surfactant; nanocarrier; Polymersome
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