Shokrgozar, Mohammad Ali, Mottaghitalab, Fatemeh, Mottaghitalab, Vahid, Farrokhi, Mehdi, Eslamifar, Ali (2009). Evaluation of chitosan/poly (vinyl alcohol) nano-composite biocompatibility for neural cells proliferation. , 12(3), 51-60.
Mohammad Ali Shokrgozar; Fatemeh Mottaghitalab; Vahid Mottaghitalab; Mehdi Farrokhi; Ali Eslamifar. "Evaluation of chitosan/poly (vinyl alcohol) nano-composite biocompatibility for neural cells proliferation". , 12, 3, 2009, 51-60.
Shokrgozar, Mohammad Ali, Mottaghitalab, Fatemeh, Mottaghitalab, Vahid, Farrokhi, Mehdi, Eslamifar, Ali (2009). 'Evaluation of chitosan/poly (vinyl alcohol) nano-composite biocompatibility for neural cells proliferation', , 12(3), pp. 51-60.
Shokrgozar, Mohammad Ali, Mottaghitalab, Fatemeh, Mottaghitalab, Vahid, Farrokhi, Mehdi, Eslamifar, Ali Evaluation of chitosan/poly (vinyl alcohol) nano-composite biocompatibility for neural cells proliferation. , 2009; 12(3): 51-60.

Evaluation of chitosan/poly (vinyl alcohol) nano-composite biocompatibility for neural cells proliferation

Pathobiology Reserach
Article 6, Volume 12, Issue 3, 2009, Pages 51-60    PDF (357.72 K)
Authors
Mohammad Ali Shokrgozar* 1; Fatemeh Mottaghitalab2; Vahid Mottaghitalab3; Mehdi Farrokhi1; Ali Eslamifar4
1Department of National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran
2Department of Biology, Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
3Department of Textile Engineering, Faculty of Engineering, Guilan University, Rasht, Iran
4Department of Clinical Research, Pasteur Institute of Iran, Tehran, Iran
Abstract
Objective: Tissue engineering is an (interdisciplinary field that applies polymeric scaffolds to control tissue formation in three-dinemtion (3D). The scaffold provides the microenvironment (synthetic temporary extracellular matrix) for regenerative cells, supporting cell attachment, proliferation, differentiation, and neo tissue genesis due to their suitable chemical, physical and biological structures. In this study, chitosan/poly (vinyl alcohol) (CS/PVA) was exploited as scaffold for nerve regeneration.
Materials and Methods: Electrospinning was used to fabricate CS/PVA nanocomposites for U373 cells seeding and proliferation. Electrospinning is a versatile and simple method to fabricate non-woven thin layer fibers from polymeric solutions. Consequently, the biocompatibility of CS/PVA nanocomposite was evaluated using biological assays and cell attachment study.
Results: Results indicated that CS/PVA nanocomposites with 15/85 proportion shown an almost homogenous network of the electrospun fibers and confirmed that they can be knitted in meshes and improve U373 cells proliferation and cell attachment.
Conclusion: The nano-sized CS/PVA scaffolds are nontoxic and biocompatible which can promote proliferation of U373 cells and their appropriate adhesion to nanocomposite for improved peripheral nerve regeneration.
Keywords
Tissue engineering; Nanocomposite; Chitosan; Poly (vinyl alcohol); Electrospinning
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