Aminian, Alieh, Solati-Hashjin, Mehran, Samadikuchaksaraei, Ali, Bakhshi, Farhad, Farzadi, Arghavan (2010). Bioactivity enhancement of hydroxyapatite by silicon substitution. , 13(3), 11-21.
Alieh Aminian; Mehran Solati-Hashjin; Ali Samadikuchaksaraei; Farhad Bakhshi; Arghavan Farzadi. "Bioactivity enhancement of hydroxyapatite by silicon substitution". , 13, 3, 2010, 11-21.
Aminian, Alieh, Solati-Hashjin, Mehran, Samadikuchaksaraei, Ali, Bakhshi, Farhad, Farzadi, Arghavan (2010). 'Bioactivity enhancement of hydroxyapatite by silicon substitution', , 13(3), pp. 11-21.
Aminian, Alieh, Solati-Hashjin, Mehran, Samadikuchaksaraei, Ali, Bakhshi, Farhad, Farzadi, Arghavan Bioactivity enhancement of hydroxyapatite by silicon substitution. , 2010; 13(3): 11-21.

Bioactivity enhancement of hydroxyapatite by silicon substitution

Pathobiology Reserach
Article 2, Volume 13, Issue 3, 2010, Pages 11-21    PDF (1.81 M)
Authors
Alieh Aminian1; Mehran Solati-Hashjin* 1; Ali Samadikuchaksaraei2; Farhad Bakhshi1; Arghavan Farzadi3
1Biomaterials Group, Biomedical Engineering Faculty, Amirkabir University of Technology, Tehran, Iran
2Department of Biotechnology, Cellular & Molecular Research Center, Iran University of Medical Science, Tehran, Iran
3No. 424, Hafez Ave. Amirkabir university of technology, Biomedical Engineering Faculty
Abstract
Objective: Silicon is an effective element in bone biomineralization; hence Si-substituted hydroxyapatite can be a relevant bioceramic as bone materials substitution.
Materials and Methods: Stoichiometric hydroxyapatite (HA) and Si-substituted hydroxyapatite (Si-HA) with different contents of Si substitution were synthesized successfully by a hydrothermal method using Ca(NO3)2, (NH4)3PO4 or (NH4)2HPO4 and Si(OCH2CH3)4 (TEOS) as starting materials.
Results: Crystalline Phases, chemical composition, microstructure and morphology of synthesized powders were investigated using X-ray diffraction (XRD), Fourier transform IR spectroscopy (FTIR), inductively coupled plasma AES (ICP-AES) and scanning electron microscopy (SEM) techniques. The results proved silicon substitution in hydroxyapatite structure and revealed that the substitution of phosphate groups by silicate groups caused some OH- loss to maintain charge balance and the lattice parameters slightly changed with respect to stoichiometric HA.
Conclusion: Si-incorporation reduces the crystallites size of Si-HA and crystallinity, thus the solubility of Si-HA powders increases, and as a result Si- substitution has improved bioactivity behavior of HA. Based on in-vitro tests; soaking and incubating the specimens in simulated body fluid (SBF) and MTT assays (Dimethylthiazol assay), Si-substituted hydroxyapatite is more bioactive than pure hydroxyapatite.
Keywords
hydrothermal; Hydroxyapatite; substitution; Silicon; Bioactivity
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