Jaafari, Abdeslam, Lekchiri, Souad, Zahir, Hafida, Ellouali, Mostafa, Badou, Abdallah, Latrache, Hassane (2021). A Cross-Immunity between SARS-CoV-2 and MERS-CoV: Interest in Anti-SARS-CoV-2 Serotherapy Development Using Dromedary Serum. , 7(2), 161-172. doi: 10.52547/iem.7.2.161
Abdeslam Jaafari; Souad Lekchiri; Hafida Zahir; Mostafa Ellouali; Abdallah Badou; Hassane Latrache. "A Cross-Immunity between SARS-CoV-2 and MERS-CoV: Interest in Anti-SARS-CoV-2 Serotherapy Development Using Dromedary Serum". , 7, 2, 2021, 161-172. doi: 10.52547/iem.7.2.161
Jaafari, Abdeslam, Lekchiri, Souad, Zahir, Hafida, Ellouali, Mostafa, Badou, Abdallah, Latrache, Hassane (2021). 'A Cross-Immunity between SARS-CoV-2 and MERS-CoV: Interest in Anti-SARS-CoV-2 Serotherapy Development Using Dromedary Serum', , 7(2), pp. 161-172. doi: 10.52547/iem.7.2.161
Jaafari, Abdeslam, Lekchiri, Souad, Zahir, Hafida, Ellouali, Mostafa, Badou, Abdallah, Latrache, Hassane A Cross-Immunity between SARS-CoV-2 and MERS-CoV: Interest in Anti-SARS-CoV-2 Serotherapy Development Using Dromedary Serum. , 2021; 7(2): 161-172. doi: 10.52547/iem.7.2.161

A Cross-Immunity between SARS-CoV-2 and MERS-CoV: Interest in Anti-SARS-CoV-2 Serotherapy Development Using Dromedary Serum

Infection Epidemiology and Microbiology
Article 7, Volume 7, Issue 2, 2021, Pages 161-172    PDF (488.3 K)
Document Type: Qualitative Research
DOI: 10.52547/iem.7.2.161
Authors
Abdeslam Jaafari* 1; Souad Lekchiri1; Hafida Zahir1; Mostafa Ellouali1; Abdallah Badou2; Hassane Latrache1
11. Bioprocess and Biointerface Laboratory, Faculty of Science and Techniques, Sultan MoulaySlimane University, BP: 523, BeniMellal, 23000, Morocco
22. Cellular and Molecular Pathology Laboratory, Faculty of Medicine and Pharmacy, University Hassan II, Casablanca, Morocco
Abstract
Backgrounds: A potential cross-immunity between SARS-CoV-2 and MERS-CoV could lead to the development of a serodiagnostic test and/or serotherapy against SARS-CoV-2 using dromedary camel anti MERS-CoV serum.

Materials & Methods: Epidemiological and 66 literature data, of which 35 have been published during 2015-2021, and findings were analysed.

Findings: According to the statistical data reported during COVID-19 pandemic, there are less cases and deaths associated with COVID-19 in countries known for dromedary breeding and the circulation of MERS-CoV (another betacoronavirus disease transmitted by dromedary camels) among humans and dromedaries. This observation and the similarity in genome and immunopathogenicity between SARS-CoV-2 and MERS-CoV, suggest that individuals who have been in contact with MERS-CoV infected dromedaries and/or consumed their products (milk, meat, urine) might have acquired an immunity protecting them against SARS-CoV-2. In addition to neutralizing antibodies, this immunity could also be due to complement proteins, chemokines, and especially antimicrobial peptides (AMP), known for their effect on enveloped viruses.

Conclusion: Most research has focused on vaccines as a solution to stop the pandemic, while serotherapy hasn’t significantly aroused the interest of researchers. This potential cross-immunity between SARS-CoV-2 and MERS-CoV could lead to the development of a serodiagnostic test and/or serotherapy against SARS-CoV-2 using dromedary camel anti MERS-CoV serum.
Keywords
SARS-CoV-2; MERS-CoV; Cross-immunity; Serotherapy
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