Haghighi, Mehrdad, Hatami, Hossein, Aryannezhad, Shayan, Delbari, Negar (2021). Risk Factors of Mortality among Hospitalized COVID-19 Patients in A Large University Hospital in Tehran, Iran. , 7(2), 141-154. doi: 10.52547/iem.7.2.141
Mehrdad Haghighi; Hossein Hatami; Shayan Aryannezhad; Negar Delbari. "Risk Factors of Mortality among Hospitalized COVID-19 Patients in A Large University Hospital in Tehran, Iran". , 7, 2, 2021, 141-154. doi: 10.52547/iem.7.2.141
Haghighi, Mehrdad, Hatami, Hossein, Aryannezhad, Shayan, Delbari, Negar (2021). 'Risk Factors of Mortality among Hospitalized COVID-19 Patients in A Large University Hospital in Tehran, Iran', , 7(2), pp. 141-154. doi: 10.52547/iem.7.2.141
Haghighi, Mehrdad, Hatami, Hossein, Aryannezhad, Shayan, Delbari, Negar Risk Factors of Mortality among Hospitalized COVID-19 Patients in A Large University Hospital in Tehran, Iran. , 2021; 7(2): 141-154. doi: 10.52547/iem.7.2.141

Risk Factors of Mortality among Hospitalized COVID-19 Patients in A Large University Hospital in Tehran, Iran

Infection Epidemiology and Microbiology
Article 5, Volume 7, Issue 2, 2021, Pages 141-154    PDF (492.6 K)
Document Type: Original Research
DOI: 10.52547/iem.7.2.141
Authors
Mehrdad Haghighi1; Hossein Hatami2; Shayan Aryannezhad3; Negar Delbari* 3
1Department of Infectious Diseases, Imam Hossein Teaching and Medical Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2Department of Public Health, School of Public Health and Safety and Environmental and Occupational Hazards Control Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract
Backgrounds: Coronavirus disease 2019 (COVID-19) pandemic is considered as a global health challenge, and Iran is among the top ten countries with the highest mortality rate. This study aimed to analyze epidemiological, clinical, and laboratory features of hospitalized SARS-CoV-2 infected patients and identify the risk factors of mortality among them to facilitate the prioritization of resources and vaccine allocation in the population using data available in a large university hospital in Tehran, Iran.

Materials & Methods: From February 20 to May 14, 2020, a total of 684 COVID-19 confirmed cases were admitted to Imam Hossein University hospital in Tehran and enrolled in this retrospective observational study.

Findings: The mean age of the participants was 59.48±16.65 years, and 55.8% were male. Compared to survivors, non-survivors (n=127, 18.57%) were older (69.09±14.16 vs. 57.29±16.40), had higher average number of comorbidities, and more frequently suffered from dyspnea, convulsion, loss of consciousness (LOC), tachycardia, tachypnea, and hypoxia. They also had higher levels of leukocytes, neutrophil count, C-reactive protein (CRP), creatine phosphokinase (CPK), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), international normalized ratio (INR), prothrombin time (PT), partial thromboplastin time (PTT), urea, and serum creatinine (p<.05). Serum potassium (K), lymphocyte count, hemoglobin, HCO3, and serum sodium (Na) were significantly lower in non-survivors. Multivariable logistic regression analysis results revealed that nine variables were positively associated with mortality.

Conclusion: Among COVID-19 patients admitted to the hospital, having more than two or three comorbidities, loss of consciousness, SpO2 < 90%, increased CRP, CPK, urea, and serum potassium, were associated with mortality.
Keywords
SARS-CoV-2; Covid-19; Risk Factors; mortality
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