The Review of SARS-CoV-2: Recent Perspective and Advances in Detection | ||
| Infection Epidemiology and Microbiology | ||
| Article 8, Volume 6, Issue 3, 2020, Pages 229-249 PDF (705.86 K) | ||
| Document Type: Analytic Review | ||
| DOI: 10.29252/iem.6.3.229 | ||
| Authors | ||
| Hajar Mohammadi Barzelighi1; Bahram Daraei* 2 | ||
| 1Biosun Pharmed Factory, Barkat Pharmaceutical group, Tehran, Iran | ||
| 2Department of Toxicology and Pharmacology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran | ||
| Abstract | ||
| Background: The outbreak of novel coronavirus (2019-nCoV), which began in Wuhan, China, has rapidly spread in many countries and is currently considered a pandemic. The virus (SARS-CoV-2) causes severe acute respiratory syndrome and is related to SARS-CoV and MERS-CoV. Methods: In this review, an introduction to SARS-CoV-2 was provided comprising the following items: general features; pathogenesis; the existing knowledge on immunological properties; transmission routs; diagnostic features, especially discussion about new approaches for treatment and prevention; and different diagnostic methods including nucleic acid based assays, serological testing, and MALDI TOF-MS and LC-MS technologies. Findings and Conclusion: Introducing the different methods for SARS-CoV-2 detection may be useful to provide new insights into the development and improvement of detection primers, probes, methods/techniques, potential targets for drug designation, and therapeutic candidates against the virus. | ||
| Keywords | ||
| 2019-nCoV; Acute Respiratory syndrome; Nucleic acid base assays; Serological testing; MALDI TOF-MS and LC-MS | ||
| References | ||
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