Bahroudi, S., Nematollahi, M.A., Aghasadeghi, M.R., Nazemi, M. (2018). In vitro Evaluation of the Antiviral Activity and Cytotoxicity Effect of Holothuria leucospilota Sea Cucumber Extracts from the Persian Gulf. , 4(4), 153-157.
S. Bahroudi; M.A. Nematollahi; M.R. Aghasadeghi; M. Nazemi. "In vitro Evaluation of the Antiviral Activity and Cytotoxicity Effect of Holothuria leucospilota Sea Cucumber Extracts from the Persian Gulf". , 4, 4, 2018, 153-157.
Bahroudi, S., Nematollahi, M.A., Aghasadeghi, M.R., Nazemi, M. (2018). 'In vitro Evaluation of the Antiviral Activity and Cytotoxicity Effect of Holothuria leucospilota Sea Cucumber Extracts from the Persian Gulf', , 4(4), pp. 153-157.
Bahroudi, S., Nematollahi, M.A., Aghasadeghi, M.R., Nazemi, M. In vitro Evaluation of the Antiviral Activity and Cytotoxicity Effect of Holothuria leucospilota Sea Cucumber Extracts from the Persian Gulf. , 2018; 4(4): 153-157.

In vitro Evaluation of the Antiviral Activity and Cytotoxicity Effect of Holothuria leucospilota Sea Cucumber Extracts from the Persian Gulf

Infection Epidemiology and Microbiology
Article 6, Volume 4, Issue 4 - Serial Number 13, 2018, Pages 153-157    PDF (615.44 K)
Document Type: Original Research
Authors
S. Bahroudi1; M.A. Nematollahi* 1; M.R. Aghasadeghi2; M. Nazemi3
1Fisheries Department, Natural Resources Faculty, University of Tehran, Karaj, Iran
2Hepatitis & AIDS Departments, Pasteur Institute of Iran, Tehran, Iran
3Persian Gulf & Oman Sea Ecological Research Institute, Bandar Abbas, Hormozgan, Iran
Abstract
Aims: Antiviral activity and effect of methanol and diethyl ether extracts from different parts of sea cucumber (Holothuria leucospilota) against HIV-1 were assessed on human oral epidermoid carcinoma cells (KB) and Human embryonic kidney 293T cells (HEK293T).

Materials & Methods: Sea cucumber was collected at a depth of 10-30 m (Persian Gulf). Extracts were prepared by diethyl ether and methanol solvents. The antiviral activity of each extract was evaluated by inhibition of single-cycle HIV-1 (SCR HIV-1) p24 Core antigen production in HeLa cells and cellular toxicity of different extracts were assessed, using a cell proliferation XTT kit.

Findings: Antiviral activity of each extract showed that some concentrations were able to inhibit the replication of HIV-1. Diethyl ether extract of body wall with 2.79 TI index displayed the highest antiviral activity as well as less effect.

Conclusion: This study showed that crude extracts of Holothuria leucospilota, especially methanol and diethyl ether extracts of digestive organs and body wall and antiviral activity, respectively.
Keywords
Sea cucumber; Antiviral; Cytotoxicity; Persian Gulf; Holothuria leucospilota
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